Ccdc80^tm1Ppal
Targeted Allele Detail

Summary

• Symbol: Ccdc80^tm1Ppal
• Name: coiled-coil domain containing 80; targeted mutation 1, Pierlorenzo Pallante
• MGI ID: MGI:5706809
• Synonyms: cl2/ccdc80^-
• Gene: Ccdc80 Location: Chr16:44913770-44948287 bp, + strand Genetic Position: Chr16, 29.39 cM, cytoband B5
• Alliance: Ccdc80^tm1Ppal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217742
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic region including all of exon 1 and most of exon 2 (including the translational start site) was replaced with a neo cassette via homologous recombination. RT-PCR analysis confirmed lack of RNA expression in thyroid, spleen, ovary, liver and kidney tissue from homozygous mutant mice. (J:217742)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccdc80 Mutation: 52 strains or lines available

References

• Original: J:217742 Leone V, et al., The cl2/dro1/ccdc80 null mice develop thyroid and ovarian neoplasias. Cancer Lett. 2015 Feb 28;357(2):535-41
• All: 1 reference(s)