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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Uri1tm1.1Ndj
targeted mutation 1.1, Nabil Djouder
MGI:5706757
Summary 2 genotypes


Genotype
MGI:6378449
cn1
Allelic
Composition		 Uri1tm1.1Ndj/Uri1tm1.1Ndj
Albtm1(cre/ERT2)Mtz/Alb+
Genetic
Background		 B6.Cg-Albtm1(cre/ERT2)Mtz Uri1tm1.1Ndj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Albtm1(cre/ERT2)Mtz mutation (1 available); any Alb mutation (91 available)
Uri1tm1.1Ndj mutation (0 available); any Uri1 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:217463 )
• tamoxifen-treated mice die around 10 days of age probably from fulminant liver failure

liver/biliary system
liver hemorrhage ( J:217463 )
• tamoxifen-treated mice show dilated veins with intrahepatic bleeding
increased hepatocyte apoptosis ( J:217463 )
• Sirius Red staining, collapsed reticulin fibers, and increased ALT levels in tamoxifen-treated mice indicate that hepatocytes undergo massive apoptosis, leading to liver injury
liver inflammation ( J:217463 )
• tamoxifen-treated mice exhibit inflammatory cell infiltration in the liver
abnormal liver morphology ( J:217463 )
• tamoxifen-treated mice exhibit disruption of liver tissue architecture, presence of atypia, dilated veins with intrahepatic bleeding, signs of necrosis and inflammatory cell infiltration
hepatic necrosis ( J:217463 )
• in tamoxifen-treated mice

homeostasis/metabolism
increased circulating alanine transaminase level ( J:217463 )
• tamoxifen-treated mice show increased alanine transaminase (ALT) levels

cardiovascular system
liver hemorrhage ( J:217463 )
• tamoxifen-treated mice show dilated veins with intrahepatic bleeding

immune system
liver inflammation ( J:217463 )
• tamoxifen-treated mice exhibit inflammatory cell infiltration in the liver

cellular
increased hepatocyte apoptosis ( J:217463 )
• Sirius Red staining, collapsed reticulin fibers, and increased ALT levels in tamoxifen-treated mice indicate that hepatocytes undergo massive apoptosis, leading to liver injury
hepatic necrosis ( J:217463 )
• in tamoxifen-treated mice




Genotype
MGI:6378450
cn2
Allelic
Composition		 Uri1tm1.1Ndj/Uri1+
Albtm1(cre/ERT2)Mtz/Alb+
Genetic
Background		 B6.Cg-Albtm1(cre/ERT2)Mtz Uri1tm1.1Ndj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Albtm1(cre/ERT2)Mtz mutation (1 available); any Alb mutation (91 available)
Uri1tm1.1Ndj mutation (0 available); any Uri1 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal enzyme/coenzyme level ( J:217463 )
• NAD+ levels are increased in tamoxifen-treated livers
decreased incidence of tumors by chemical induction ( J:217463 )
• tamoxifen-treated mice treated with diethylnitrosamine (DEN) do not show tumors at 24 weeks of age as seen in 60% of control mice and show normal alanine transaminase levels
decreased susceptibility to injury ( J:217463 )
• tamoxifien-treated mice supplied with a liver damage-inducing 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DCC)-supplemented diet present less liver damage and fibrosis

neoplasm
decreased incidence of tumors by chemical induction ( J:217463 )
• tamoxifen-treated mice treated with diethylnitrosamine (DEN) do not show tumors at 24 weeks of age as seen in 60% of control mice and show normal alanine transaminase levels




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory