Analysis Tools
vision/eye
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• mice exhibit age-related loss of retinal ganglion cells, with a 40% decrease in retinal ganglion cell density at 18 months of age
• however, mice exhibit normal eye anatomy and intraocular pressure, no loss of retinal layers, and unaffected retinal ganglion cell axonal targeting
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• increase in stressed or degenerating axons in optic nerves
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• 18 month old mice show attenuated visual acuity response at 0.05 cpd, but not other acuity levels despite normal acuity thresholds
• however, nerve conduction velocity is normal
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• 18 month old mice show a decrease in contrast sensitivity across a range of contrasts
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nervous system
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• mice exhibit age-related loss of retinal ganglion cells, with a 40% decrease in retinal ganglion cell density at 18 months of age
• however, mice exhibit normal eye anatomy and intraocular pressure, no loss of retinal layers, and unaffected retinal ganglion cell axonal targeting
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• increase in stressed or degenerating axons in optic nerves
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• increase in stressed or degenerating axons in optic nerves
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| primary open angle glaucoma | DOID:1070 |
OMIM:137760 |
J:222642 | |
