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Transgene Detail
Symbol: Tg(OPTN*E50K,-EGFP)1Mde
Name: transgene insertion 1, Michael D Ehlers
MGI ID: MGI:5705748
Synonyms: BAC-hOPTNE50K
Transgene: Tg(OPTN*E50K,-EGFP)1Mde  Location: unknown  
Alliance: Tg(OPTN*E50K,-EGFP)1Mde page
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Tg(OPTN*E50K,-EGFP)1Mde expresses 1 gene
Mutation detailsThe transgene is composed of BAC clone RP11-1107F3 containing the 38 kb-human OPTN locus with about 160 kb of 5 sequence containing the E50K mutation in the middle (GAG to AAG) and a fragment containing the internal ribosome entry site-enhanced green fluorescent protein. Two lines were established, 1 and 2. Line 1 shows overexpression of the gene but line 2 does not. Quantitative rtPCR and immunoblot analysis confirmed mRNA expression and protein expression in the retina. (J:222642)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:222642 Tseng HC, et al., Visual impairment in an optineurin mouse model of primary open-angle glaucoma. Neurobiol Aging. 2015 Jun;36(6):2201-12
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory