All Phenotypes Mir182<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mir182⁺
wild type
MGI:5704426

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kras^tm4Tyj/Kras^tm4Tyj Mir182^tm1.1Dgk/Mir182⁺ Trp53^tm1Brn/Trp53^tm1Brn	involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:5704427

Allelic Composition	Kras^tm4Tyj/Kras^tm4Tyj Mir182^tm1.1Dgk/Mir182⁺ Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (11 available); any Kras mutation (69 available)
Mir182^tm1.1Dgk mutation (1 available); any Mir182 mutation (9 available)
Trp53^tm1Brn mutation (20 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased metastatic potential ( J:217635 )

• 20% of mice develop lung metastases by 120 days following amputation of limb injected with cre-expressing adenovirus

• in the absence of the Mir18^tm1.1Dgk allele, 43% of mice develop lung metastases

• number of metastatic nodules and metastatic burden in the lung are decreased compared to mice without the Mir18^tm1.1Dgk allele

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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