All Phenotypes Cbfb<tm2.1Ddg> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cbfb^tm2.1Ddg
targeted mutation 2.1, David D Ginty
MGI:5698728

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cbfb^tm2.1Ddg/Cbfb^tm2.1Ddg Mapt^tm2Arbr/? H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J	MGI:5702479
cn2	Cbfb^tm2.1Ddg/Cbfb^tm2.1Ddg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S6/SvEvTac * C57BL/6J * CBA/J	MGI:5702482
cn3	Cbfb^tm2.1Ddg/Cbfb^tm2.1Ddg Mapt^tm2Arbr/? Runx1^{tm1(cre/Esr1*)Ims}/?	involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj	MGI:5702484

Allelic Composition	Cbfb^tm2.1Ddg/Cbfb^tm2.1Ddg Mapt^tm2Arbr/? H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfb^tm2.1Ddg mutation (1 available); any Cbfb mutation (36 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (428 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal sensory neuron innervation pattern ( J:226826 )

• reduction of sensory innervation of the epidermis at P0

abnormal axon morphology ( J:226826 )

• reduction in epidermal nerve fiber density

abnormal nociceptor morphology ( J:226826 )

• deficiency of peripheral projections of nonpeptidergic (mechanical) nociceptors

craniofacial

abnormal craniofacial development ( J:226826 )

mortality/aging

perinatal lethality ( J:226826 )

• mice die perinatally due to craniofacial defects

Allelic Composition	Cbfb^tm2.1Ddg/Cbfb^tm2.1Ddg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal craniofacial development ( J:226826 )

mortality/aging

perinatal lethality ( J:226826 )

• mice die perinatally due to craniofacial defects

Allelic Composition	Cbfb^tm2.1Ddg/Cbfb^tm2.1Ddg Mapt^tm2Arbr/? Runx1^{tm1(cre/Esr1*)Ims}/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfb^tm2.1Ddg mutation (1 available); any Cbfb mutation (36 available)
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (428 available)
Runx1^{tm1(cre/Esr1*)Ims} mutation (0 available); any Runx1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal mechanoreceptor morphology ( J:226826 )

• few or no tyrosine hydroxylase C-low threshold mechanoreceptors (C-LTMRs) are observed in P21 mice following tamoxifen administration at P2

• decrease in the number of longitudinal lanceolate endings (characteristic of C-LTMRs) in back hairy skin of P21 mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23