All Phenotypes Dock2<m5Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dock2^m5Btlr
mutation 5, Bruce Beutler
MGI:5695264

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dock2^m5Btlr/Dock2^m5Btlr	C57BL/6J-Dock2^m5Btlr	MGI:5695303
ht2	Dock2^m5Btlr/Dock2⁺	C57BL/6J-Dock2^m5Btlr	MGI:5695304

Allelic Composition	Dock2^m5Btlr/Dock2^m5Btlr
Genetic Background	C57BL/6J-Dock2^m5Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2^m5Btlr mutation (0 available); any Dock2 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:225938 )

abnormal CD4-positive T cell differentiation ( J:225938 )

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225938 )

impaired hematopoiesis ( J:225938 )

increased B cell number ( J:225938 )

decreased CD4-positive, alpha-beta T cell number ( J:225938 )

increased CD8-positive, alpha-beta T cell number ( J:225938 )

decreased single-positive T cell number ( J:225938 )

increased single-positive T cell number ( J:225938 )

immune system

abnormal B cell differentiation ( J:225938 )

abnormal CD4-positive T cell differentiation ( J:225938 )

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225938 )

increased B cell number ( J:225938 )

decreased CD4-positive, alpha-beta T cell number ( J:225938 )

increased CD8-positive, alpha-beta T cell number ( J:225938 )

decreased single-positive T cell number ( J:225938 )

increased single-positive T cell number ( J:225938 )

Allelic Composition	Dock2^m5Btlr/Dock2⁺
Genetic Background	C57BL/6J-Dock2^m5Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2^m5Btlr mutation (0 available); any Dock2 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:225938 )

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225938 )

impaired hematopoiesis ( J:225938 )

decreased CD4-positive, alpha-beta T cell number ( J:225938 )

increased CD8-positive, alpha-beta T cell number ( J:225938 )

decreased single-positive T cell number ( J:225938 )

increased single-positive T cell number ( J:225938 )

immune system

abnormal CD4-positive T cell differentiation ( J:225938 )

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225938 )

decreased CD4-positive, alpha-beta T cell number ( J:225938 )

increased CD8-positive, alpha-beta T cell number ( J:225938 )

decreased single-positive T cell number ( J:225938 )

increased single-positive T cell number ( J:225938 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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