All Phenotypes Dock2<m5Btlr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dock2^m5Btlr
mutation 5, Bruce Beutler
MGI:5695264

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	\Dock2^m5Btlr/\Dock2^m5Btlr	C57BL/6J-Dock2^m5Btlr	MGI:5695303
ht2	\Dock2^m5Btlr/\Dock2⁺	C57BL/6J-Dock2^m5Btlr	MGI:5695304

Allelic Composition	\Dock2^m5Btlr/\Dock2^m5Btlr
Genetic Background	C57BL/6J-Dock2^m5Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2^m5Btlr mutation (0 available); any Dock2 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:225938 )

abnormal CD4-positive T cell differentiation ( J:225938 )

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225938 )

impaired hematopoiesis ( J:225938 )

increased B cell number ( J:225938 )

decreased CD4-positive, alpha-beta T cell number ( J:225938 )

increased CD8-positive, alpha-beta T cell number ( J:225938 )

decreased single-positive T cell number ( J:225938 )

increased single-positive T cell number ( J:225938 )

immune system

abnormal B cell differentiation ( J:225938 )

abnormal CD4-positive T cell differentiation ( J:225938 )

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225938 )

increased B cell number ( J:225938 )

decreased CD4-positive, alpha-beta T cell number ( J:225938 )

increased CD8-positive, alpha-beta T cell number ( J:225938 )

decreased single-positive T cell number ( J:225938 )

increased single-positive T cell number ( J:225938 )

Allelic Composition	\Dock2^m5Btlr/\Dock2⁺
Genetic Background	C57BL/6J-Dock2^m5Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2^m5Btlr mutation (0 available); any Dock2 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:225938 )

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225938 )

impaired hematopoiesis ( J:225938 )

decreased CD4-positive, alpha-beta T cell number ( J:225938 )

increased CD8-positive, alpha-beta T cell number ( J:225938 )

decreased single-positive T cell number ( J:225938 )

increased single-positive T cell number ( J:225938 )

immune system

abnormal CD4-positive T cell differentiation ( J:225938 )

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225938 )

decreased CD4-positive, alpha-beta T cell number ( J:225938 )

increased CD8-positive, alpha-beta T cell number ( J:225938 )

decreased single-positive T cell number ( J:225938 )

increased single-positive T cell number ( J:225938 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24