Phenotypes associated with this allele

• Allele Symbol: Del(16Dyrk1a-Kcnj6)14Yey
• Allele Name: deletion, Chr 16, Y Eugene Yu 14
• Allele ID: MGI:5689441
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Del(16Dyrk1a-Kcnj6)14Yey/+	B6.129S7-Del(16Dyrk1a-Kcnj6)14Yey	MGI:5690047
cx2	Del(16Dyrk1a-Kcnj6)14Yey/Dp(16Lipi-Zbtb21)1Yey	B6.129S7-Del(16Dyrk1a-Kcnj6)14Yey/Dp(16Lipi-Zbtb21)1Yey	MGI:5690044

Genotype
MGI:5690047

ht1

• Allelic Composition: Del(16Dyrk1a-Kcnj6)14Yey/+
• Genetic Background: B6.129S7-Del(16Dyrk1a-Kcnj6)14Yey

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

transmission ratio distortion ( J:224899 )

• deletion is transmitted at a ratio that is lower than expected

Genotype
MGI:5690044

cx2

• Allelic Composition: Del(16Dyrk1a-Kcnj6)14Yey/Dp(16Lipi-Zbtb21)1Yey
• Genetic Background: B6.129S7-Del(16Dyrk1a-Kcnj6)14Yey/Dp(16Lipi-Zbtb21)1Yey

behavior/neurological

impaired contextual conditioning behavior ( J:224899 )

• mice exhibit decreased freezing behavior in contextual fear-conditioning test as compared to wild type

decreased exploration in new environment ( J:224899 )

• impaired performance in T maze spontaneous alteration test as compared to wild type

nervous system

reduced long-term potentiation ( J:224899 )

• magnitude of hippocampal LTP following theta burst stimulation is lower than controls