Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13tm2Anjm mutation
(6 available);
any
Il13 mutation
(29 available)
Tg(SFTPC-Il18)AThos mutation
(0 available)
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growth/size/body
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• mice show a decrease in body weight from 16 to 24 weeks of age, however weight loss is less than seen in single transgenic Tg(SFTPC-Il18)AThos mice
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respiratory system
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• mean alveolar chord lengths of 14 week old mice is shorter than in single transgenic mice
• however, pulmonary inflammation and emphysematous changes are not seen in the lungs
enlarged alveolar macrophages and exudates are not present in the lungs
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muscle
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• decrease in quadriceps femoris muscle weight at 7 and 16 weeks of age, although muscle is heavier than in single transgenic Tg(SFTPC-Il18)AThos mice and by 25 weeks of age, weight is similar to wild-type mice
• mice show a decrease in gastrocnemius muscle weight at 7 weeks of age but not 16 and 25 weeks of age
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skeleton
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• bone mineral density is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation
(18 available);
any
Ifng mutation
(47 available)
Tg(SFTPC-Il18)AThos mutation
(0 available)
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immune system
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• mice exhibit more severe emphysematous changes and pulmonary inflammation with swelled alveolar macrophages than in single transgenic mice
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respiratory system
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• mice exhibit more severe emphysematous changes and pulmonary inflammation with swelled alveolar macrophages than in single transgenic mice
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• the mean alveolar chord length is greater than in wild-type mice and single Tg(SFTPC-Il18)AThos transgenic mice
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• mice exhibit more severe emphysematous changes and pulmonary inflammation with swelled alveolar macrophages than in single transgenic mice
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• lung volume is higher than in wild-type or single transgenic mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• mice over 10 weeks of age exhibit cardiomegaly
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• the right ventricle exhibits hypertrophy in some 8 week old mutants
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• dilation of the right ventricle dimension is seen in aged (15-17 week), but not juvenile, mice
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• mice show signs of right-sided heart failure with aging
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• the right ventricular end-diastolic pressure is higher in 20 week old mice
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• the right ventricular systolic pressure is higher in 20 week old mice
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• pulmonary hypertension is seen with aging
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growth/size/body
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• mice over 10 weeks of age exhibit cardiomegaly
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• the right ventricle exhibits hypertrophy in some 8 week old mutants
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• mice show a decrease in body weight from 16 to 24 weeks of age, but not at earlier times
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• moderate splenomegaly
• mice however, do not exhibit enteritis, glomerulonephritis, or hepatitis
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hematopoietic system
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• lymphoid follicle is enlarged in spleens
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• moderate splenomegaly
• mice however, do not exhibit enteritis, glomerulonephritis, or hepatitis
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homeostasis/metabolism
immune system
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• lymphoid follicle is enlarged in spleens
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• moderate splenomegaly
• mice however, do not exhibit enteritis, glomerulonephritis, or hepatitis
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• increase in IFN-gamma production in the lungs
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• increase in Il13 production in the lungs
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• mild interstitial inflammation in the alveolar wall is seen at around 4 weeks after birth
• inflammatory cells contain increased numbers of mononuclear ells, neutrophils, and eosinophils
• enlarged macrophages and exudates are seen in some pulmonary alveoli
• alveolar macrophages, CD8+ T cells, CD4+ T cells, CD3+ T cells, neutrophils, and eosinophils are increased in the bronchoalveolar lavage fluid; the proportion of CD8+ T cells is greater than that of CD4+ T-cells
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muscle
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• the right ventricle exhibits hypertrophy in some 8 week old mutants
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• decrease in quadriceps femoris and gastrocnemius muscle weight at 7, 16, and 25 weeks of age
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respiratory system
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• mild interstitial inflammation in the alveolar wall is seen at around 4 weeks after birth
• inflammatory cells contain increased numbers of mononuclear ells, neutrophils, and eosinophils
• enlarged macrophages and exudates are seen in some pulmonary alveoli
• alveolar macrophages, CD8+ T cells, CD4+ T cells, CD3+ T cells, neutrophils, and eosinophils are increased in the bronchoalveolar lavage fluid; the proportion of CD8+ T cells is greater than that of CD4+ T-cells
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• mean alveolar chord length is increased in males at 6 and 8 weeks of age, with a greater than 70% increase at 10 weeks of age
• mice show a wider spread of the distribution of chord length in the lungs compared to the narrow distribution in controls
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• aged (24 weeks) mice show thickening of the alveolar walls and interstitium accompanied with severe pulmonary inflammation
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• alveolar enlargement is seen around 8 weeks of age
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• mice over 10 weeks of age exhibit increased lung volumes
• however, lung formation is normal and lung fibrosis is not seen
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• static lung compliance is higher than in controls at 11 weeks of age
• static lung compliance in 24 week old mice with severe interstitial inflammation is significantly lower than in controls
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skeleton
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• decrease in bone mineral density in aged (24 weeks) mice
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