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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mrpl3em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5662430
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mrpl3em1(IMPC)J/Mrpl3em1(IMPC)J C57BL/6NJ-Mrpl3em1(IMPC)J/J MGI:6262923
ht2
 		Mrpl3em1(IMPC)J/Mrpl3+ C57BL/6NJ-Mrpl3em1(IMPC)J/J MGI:6262922


Genotype
MGI:6262923
hm1
Allelic
Composition		 Mrpl3em1(IMPC)J/Mrpl3em1(IMPC)J
Genetic
Background		 C57BL/6NJ-Mrpl3em1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrpl3em1(IMPC)J mutation (1 available); any Mrpl3 mutation (18 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
failure to gastrulate ( J:279207 )
• no morphological hallmarks typical of gastrulating embryos are observed at E7.5
embryonic growth arrest ( J:279207 )
• embryos arrest prior to gastrulation
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5
abnormal egg cylinder morphology ( J:279207 )
• a rudimentary egg cylinder is observed at E7.5
absent head fold ( J:279207 )
• no head folds are present at E7.5
absent primitive node ( J:279207 )
• no embryonic node is present at E7.5
failure of primitive streak formation ( J:279207 )
• no morphological evidence of primitive streak formation is observed at E7.5
• no Brachyury (T)-positive cells are present at E7.5, indicating failure of primitive streak initiation

growth/size/body
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5

mortality/aging
embryonic lethality prior to organogenesis ( J:211773 , J:279207 )
IMPC - JAX (J:211773)
MGI
• homozygous embryos are recovered at lower than expected Mendelian ratios at E7.5 (12% versus 25%) and arrest prior to gastrulation (J:279207)
embryonic lethality, complete penetrance ( J:279207 )
• no homozygous embryos are recovered at E9.5




Genotype
MGI:6262922
ht2
Allelic
Composition		 Mrpl3em1(IMPC)J/Mrpl3+
Genetic
Background		 C57BL/6NJ-Mrpl3em1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrpl3em1(IMPC)J mutation (1 available); any Mrpl3 mutation (18 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory