Phenotypes associated with this allele

• Allele Symbol: Mrpl44^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5662419
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrpl44^em1(IMPC)J/Mrpl44^em1(IMPC)J	C57BL/6NJ-Mrpl44^em1(IMPC)J/J	MGI:6262925

Genotype
MGI:6262925

hm1

• Allelic Composition: Mrpl44^em1(IMPC)J/Mrpl44^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Mrpl44^em1(IMPC)J/J

Data Sources

IMPC Data for Mrpl44

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

failure to gastrulate ( J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

• no Brachyury (T)-positive cells are present at E7.5, indicating failure of primitive streak initiation

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 , J:279207 )

IMPC - JAX (J:211773)

MGI

• homozygous embryos are recovered at expected Mendelian ratios at E7.5 but arrest prior to gastrulation (J:279207)

embryonic lethality, complete penetrance ( J:279207 )

• no homozygous embryos are recovered at E9.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX