All Phenotypes Tbck<tm1b(EUCOMM)Hmgu> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Tbck^{tm1b(EUCOMM)Hmgu}/Tbck^{tm1b(EUCOMM)Hmgu}
Genetic Background	B6J.B6N-Tbck^{tm1b(EUCOMM)Hmgu}
Cell Lines	HEPD0678_1_D08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbck^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Tbck mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality ( J:344893 )

• homozygotes backcrossed to C57BL/6J for six generations are embryonic lethal

Allelic Composition	Tbck^{tm1b(EUCOMM)Hmgu}/Tbck^{tm1b(EUCOMM)Hmgu}
Genetic Background	C57BL/6N-Tbck^{tm1b(EUCOMM)Hmgu}/J
Cell Lines	HEPD0678_1_D08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbck^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Tbck mutation (53 available)

Data Sources

IMPC Data for Tbck

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - JAX

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:344893 )

N	• mice exhibit normal balance and motor coordination on an accelerating rotatrod assay and show no significant differences in the overall acoustic startle response (ASR), although females respond less to stimuli of increasing decibels than wild-type controls

decreased exploration in new environment ( J:344893 )

• in a Y-maze assay, males show a significantly lower number of total arm entries than wild-type males at the 8 min timepoint; however, the number of spontaneous arm alternations is normal at all timepoints in both sexes

• in an elevated zero maze (EZM) test, females travel significantly less than males and strongly trend towards less total distance traveled than wild-type females

• however, time spent in the open areas of the EZM is not significantly altered, indicating normal anxiety-like behavior

decreased vertical activity ( J:344893 )

• in the open field test, mice rear significantly less than wild-type controls over a 10-min period, with males more severely affected than females

• however, open field total activity, horizontal activity, and center activity are normal in both sexes

nervous system

nervous system phenotype ( J:344893 )

N	• regardless of genotype, male mice show significant reductions in phospho-S6 (235/236) and p-4E-BP1 relative to female controls, indicating decreased mTORC1 signaling in male brains

decreased prepulse inhibition ( J:344893 )

• mice show a significant reduction of PPI at the 87-dB pre-pulse stimulus

• however, no differences are detected at the 78 or 81-dB pre-pulse stimuli

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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