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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igs2tm1(CAG-mt-Keima)Fink
targeted mutation 1, Toren Finkel
MGI:5660493
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igs2tm1(CAG-mt-Keima)Fink/Igs2tm1(CAG-mt-Keima)Fink either: FVBNCrl.129(Cg)-Igs2tm1(CAG-mt-Keima)Fink or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J * FVB/NCrl) MGI:5660611
cx2
 		Igs2tm1(CAG-mt-Keima)Fink/Igs2+
Lamp2tm1Psa/Lamp2tm1Psa 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:6259616


Genotype
MGI:5660611
hm1
Allelic
Composition		 Igs2tm1(CAG-mt-Keima)Fink/Igs2tm1(CAG-mt-Keima)Fink
Genetic
Background		 either: FVBNCrl.129(Cg)-Igs2tm1(CAG-mt-Keima)Fink or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J * FVB/NCrl)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs2tm1(CAG-mt-Keima)Fink mutation (0 available); any Igs2 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:270139 )
• mice are viable and fertile




Genotype
MGI:6259616
cx2
Allelic
Composition		 Igs2tm1(CAG-mt-Keima)Fink/Igs2+
Lamp2tm1Psa/Lamp2tm1Psa
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs2tm1(CAG-mt-Keima)Fink mutation (0 available); any Igs2 mutation (68 available)
Lamp2tm1Psa mutation (0 available); any Lamp2 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardial fiber physiology ( J:253728 )
• cardiomyocytes from 20 week old mice exhibit impaired delivery of damaged mitochondria to the lysosomes for degradation and increased accumulation of damaged mitochondria in the cytoplasm and within autophagic vacuoles

cellular
abnormal mitophagy ( J:253728 )
• cardiomyocytes from 20 week old mice exhibit impaired delivery of damaged mitochondria to the lysosomes for degradation and increased accumulation of damaged mitochondria in the cytoplasm and within autophagic vacuoles

homeostasis/metabolism
abnormal mitophagy ( J:253728 )
• cardiomyocytes from 20 week old mice exhibit impaired delivery of damaged mitochondria to the lysosomes for degradation and increased accumulation of damaged mitochondria in the cytoplasm and within autophagic vacuoles




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory