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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Siva1tm1.2Att
targeted mutation 1.2, Laura D Attardi
MGI:5659850
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Siva1tm1.2Att/Siva1tm1.2Att involves: 129S4/SvJae * C57BL/6 MGI:5659852
cn2
 		Krastm4Tyj/Kras+
Siva1tm1.1Att/Siva1tm1.2Att 		involves: 129S4/SvJae * C57BL/6 MGI:5659853
cn3
 		Krastm4Tyj/Kras+
Siva1tm1.2Att/Siva1+ 		involves: 129S4/SvJae * C57BL/6 MGI:5659856


Genotype
MGI:5659852
hm1
Allelic
Composition		 Siva1tm1.2Att/Siva1tm1.2Att
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Siva1tm1.2Att mutation (0 available); any Siva1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality ( J:223572 )
• no homozygous pups are produced from heterozygote x heterozygote matings




Genotype
MGI:5659853
cn2
Allelic
Composition		 Krastm4Tyj/Kras+
Siva1tm1.1Att/Siva1tm1.2Att
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Siva1tm1.1Att mutation (1 available); any Siva1 mutation (17 available)
Siva1tm1.2Att mutation (0 available); any Siva1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal lung adenoma incidence ( J:223572 )
• mice exhibit reduced numbers of both adenomas and adenocarcinomas as compared to controls following intratracheal injection of Cre expressing adenovirus (Ad-Cre)
decreased lung tumor incidence ( J:223572 )
• mice exhibit lower tumor burden (% of lung area comprising tumors) as compared to controls following intratracheal injection of Ad-Cre

respiratory system
abnormal lung epithelium morphology ( J:223572 )
• mice exhibit reduced numbers of hyperplastic lesions as compared to controls following intratracheal injection of Ad-Cre




Genotype
MGI:5659856
cn3
Allelic
Composition		 Krastm4Tyj/Kras+
Siva1tm1.2Att/Siva1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Siva1tm1.2Att mutation (0 available); any Siva1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal lung adenoma incidence ( J:223572 )
• mice exhibit reduced numbers of both adenomas and adenocarcinomas as compared to controls following intratracheal injection of Cre expressing adenovirus (Ad-Cre)
decreased lung tumor incidence ( J:223572 )
• mice exhibit lower tumor burden (% of lung area comprising tumors) as compared to controls following intratracheal injection of Ad-Cre

respiratory system
abnormal lung epithelium morphology ( J:223572 )
• mice exhibit reduced numbers of hyperplastic lesions as compared to controls following intratracheal injection of Ad-Cre




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory