About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc1tm2.1Aven
targeted mutation 2.1, Andrea Ventura
MGI:5648458
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mirc1tm2.1Aven/Mirc1tm2.1Aven B6.Cg-Mirc1tm2.1Aven MGI:5661549
hm2
 		Mirc1tm2.1Aven/Mirc1tm2.1Aven involves: 129S4/SvJae * C57BL/6 * SJL/J MGI:5661546
cx3
 		Mirc1tm2.1Aven/Mirc1tm2.1Aven
Tg(ARR2/Pbsn-MYC)7Key/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL/J MGI:5662416
cx4
 		Mirc1tm2.1Aven/Mirc1tm2.1Aven
Tg(IghMyc)22Bri/? 		involves: 129S4/SvJae * C57BL/6 * SJL/J MGI:5662410
cx5
 		Mirc1tm2.1Aven/Mirc1+
Tg(IghMyc)22Bri/? 		involves: 129S4/SvJae * C57BL/6 * SJL/J MGI:5662414


Genotype
MGI:5661549
hm1
Allelic
Composition		 Mirc1tm2.1Aven/Mirc1tm2.1Aven
Genetic
Background		 B6.Cg-Mirc1tm2.1Aven
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm2.1Aven mutation (1 available); any Mirc1 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:223213 )
• heterozygote x heterozygote matings produce 5% homozygotes rather than the expected 25%

skeleton
vertebral fusion ( J:223213 )
• 20% of mice exhibit vertebral fusion




Genotype
MGI:5661546
hm2
Allelic
Composition		 Mirc1tm2.1Aven/Mirc1tm2.1Aven
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm2.1Aven mutation (1 available); any Mirc1 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:223213 )
• decrease in total splenic B cells
decreased myeloid cell number ( J:223213 )
• decrease in total splenic myeloid cell (CD11b+) number

immune system
decreased B cell number ( J:223213 )
• decrease in total splenic B cells




Genotype
MGI:5662416
cx3
Allelic
Composition		 Mirc1tm2.1Aven/Mirc1tm2.1Aven
Tg(ARR2/Pbsn-MYC)7Key/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm2.1Aven mutation (1 available); any Mirc1 mutation (7 available)
Tg(ARR2/Pbsn-MYC)7Key mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
small prostate gland ( J:223213 )
• prostate volume is reduced compared to Tg(ARR2/Pbsn-MYC)7Key alone
decreased prostate gland tumor incidence ( J:223213 )
• prostrates from 8 week old males exhibit occasional prostatic intraepithelial neoplasia in contrast to Tg(ARR2/Pbsn-MYC)7Key alone
increased prostate gland adenocarcinoma incidence ( J:223213 )
• invasive prostatic adenocarcinoma is not observed until 14 months of age in contrast to Tg(ARR2/Pbsn-MYC)7Key alone

reproductive system
small prostate gland ( J:223213 )
• prostate volume is reduced compared to Tg(ARR2/Pbsn-MYC)7Key alone
decreased prostate gland tumor incidence ( J:223213 )
• prostrates from 8 week old males exhibit occasional prostatic intraepithelial neoplasia in contrast to Tg(ARR2/Pbsn-MYC)7Key alone
increased prostate gland adenocarcinoma incidence ( J:223213 )
• invasive prostatic adenocarcinoma is not observed until 14 months of age in contrast to Tg(ARR2/Pbsn-MYC)7Key alone

neoplasm
decreased prostate gland tumor incidence ( J:223213 )
• prostrates from 8 week old males exhibit occasional prostatic intraepithelial neoplasia in contrast to Tg(ARR2/Pbsn-MYC)7Key alone
increased prostate gland adenocarcinoma incidence ( J:223213 )
• invasive prostatic adenocarcinoma is not observed until 14 months of age in contrast to Tg(ARR2/Pbsn-MYC)7Key alone




Genotype
MGI:5662410
cx4
Allelic
Composition		 Mirc1tm2.1Aven/Mirc1tm2.1Aven
Tg(IghMyc)22Bri/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm2.1Aven mutation (1 available); any Mirc1 mutation (7 available)
Tg(IghMyc)22Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased B cell apoptosis ( J:223213 )
• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone

mortality/aging
abnormal survival ( J:223213 )
• increase in survival as compared to mice carrying Tg(IghMyc)22Bri alone and mice carrying Tg(IghMyc)22Bri and heterozygous for Mirc1tm2.1Aven

hematopoietic system
increased B cell apoptosis ( J:223213 )
• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone
abnormal pre-B cell morphology ( J:223213 )
• bone marrow of 5 week old mice is not characterized by an accumulation of pre-B cells as compared to Tg(IghMyc)22Bri

immune system
increased B cell apoptosis ( J:223213 )
• increase in pre-B cell apoptosis as compared to mice carrying Tg(IghMyc)22Bri alone
abnormal pre-B cell morphology ( J:223213 )
• bone marrow of 5 week old mice is not characterized by an accumulation of pre-B cells as compared to Tg(IghMyc)22Bri

neoplasm
increased B cell derived lymphoma incidence ( J:223213 )
• immunophenotype of B cell lymphomas is altered (increase in in IgM+ tumors) as compared to Tg(IghMyc)22Bri alone
increased tumor latency ( J:223213 )
• as compared to mice carrying only Tg(IghMyc)22Bri




Genotype
MGI:5662414
cx5
Allelic
Composition		 Mirc1tm2.1Aven/Mirc1+
Tg(IghMyc)22Bri/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm2.1Aven mutation (1 available); any Mirc1 mutation (7 available)
Tg(IghMyc)22Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
abnormal survival ( J:223213 )
• increase in survival as compared to mice carrying Tg(IghMyc)22Br




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory