Phenotypes associated with this allele

• Allele Symbol: Npffr1^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:5646536
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npffr1^tm1Lex/Npffr1^tm1Lex	involves: 129 * C57BL/6	MGI:5646537

Genotype
MGI:5646537

hm1

• Allelic Composition: Npffr1^tm1Lex/Npffr1^tm1Lex
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:214329 )

N • no changes in pubertal progression, testicular and ovarian maturation, or ovulatory dynamics are detected

increased litter size ( J:214329 )

• mean litter size is increased

nervous system

abnormal pituitary secretion ( J:214329 )

• pituitary explants show modestly higher levels of luteinizing hormone release in response to gonadotropin-releasing hormone

• pituitary explants from females fail to decrease in LH release in response to RFRP-3 unlike in wild-type controls

increased neuron number ( J:214329 )

• increase in the number of Kiss1-expressing neurons in the arcuate nucleus

homeostasis/metabolism

increased follicle stimulating hormone level ( J:214329 )

• in adult males and females

decreased luteinizing hormone level ( J:214329 )

♂ • decrease in the stimulatory effect of neurokinin B in males

♂ • luteinizing hormones rise more slowly after orchidectomy but reach levels similar to wild-type by day 40

increased luteinizing hormone level ( J:214329 )

♂ • increase in the stimulatory effect of gonadotropin-releasing hormone in males

increased circulating luteinizing hormone level ( J:214329 )

• after a 12h fast males do not show a drop in LH levels unlike in wild-type controls but after 24h fasting LH levels are similar to controls

• after 9 weeks on a high fat diet males do not show a decrease in LH levels unlike wild-type males

• orchidectomized males fail to decrease circulating levels of LH in response to 5nmol RFRP-3 unlike in wild-type controls

• elevated levels are detected in males but not females before and during puberty

• elevated levels in females in the first 48h after ovariectomy

growth/size/body

increased susceptibility to weight loss ( J:214329 )

♂ • males show greater weight loss during a 24h fast

endocrine/exocrine glands

abnormal pituitary secretion ( J:214329 )

• pituitary explants show modestly higher levels of luteinizing hormone release in response to gonadotropin-releasing hormone

• pituitary explants from females fail to decrease in LH release in response to RFRP-3 unlike in wild-type controls