Npffr1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Npffr1^tm1Lex
• Name: neuropeptide FF receptor 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5646536
• Gene: Npffr1 Location: Chr10:61431271-61464344 bp, + strand Genetic Position: Chr10, 32.24 cM
• Alliance: Npffr1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214329
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 3 was replaced with a lacZ-neo cassette via homologous recombination. RT-PCR analysis confirmed the absence of wild-type RNA expression in multiple tissues from homozygous mice. (J:214329)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npffr1 Mutation: 17 strains or lines available

References

• Original: J:214329 Leon S, et al., Physiological roles of gonadotropin-inhibitory hormone signaling in the control of mammalian reproductive axis: studies in the NPFF1 receptor null mouse. Endocrinology. 2014 Aug;155(8):2953-65
• All: 3 reference(s)