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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(ANPEP)270Mmul
transgene insertion 270, Mathias Muller
MGI:5645778
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Stat1tm1Dlv/Stat1tm1Dlv
Tg(ANPEP)270Mmul/Tg(ANPEP)270Mmul
involves: 129S/SvEv * ICR MGI:6403902
tg2
Tg(ANPEP)270Mmul/Tg(ANPEP)270Mmul involves: ICR MGI:6403906


Genotype
MGI:6403902
cx1
Allelic
Composition
Stat1tm1Dlv/Stat1tm1Dlv
Tg(ANPEP)270Mmul/Tg(ANPEP)270Mmul
Genetic
Background
involves: 129S/SvEv * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1tm1Dlv mutation (6 available); any Stat1 mutation (51 available)
Tg(ANPEP)270Mmul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice inoculated through oral, intranasal, intragastic and intraperitoneal routes with an adapted human coronavirus 229E (HCoV-229E) that was produced by propagating the virus for 4 passages at 37 degrees Celsius on primary embryonic fibroblasts (HCoV-229E-37) are permissive to infection, showing large amounts of virus in the lungs and the gut, and also in the spleen and liver, with mice surviving at least 18 days after infection, showing a mild loss of weight and slight temperature increase, and hemorrhaging areas in lung and small intestines
• mice administered HCoV-229E-37 through the nasal route show virus growth in the lung but not in the gut, liver or spleen

cardiovascular system
• mice challenged with HCoV-229E-37 by the different routes show hemorrhaging areas in lung and small intestine, mainly between 2 and 4 days post infection

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Coronavirus infectious disease DOID:0080599 J:99728




Genotype
MGI:6403906
tg2
Allelic
Composition
Tg(ANPEP)270Mmul/Tg(ANPEP)270Mmul
Genetic
Background
involves: ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ANPEP)270Mmul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice are not susceptible to infection with an adapted human coronavirus 229E (HCoV-229E) that was produced by propagating the virus for 4 passages at 37 degrees Celsius on primary embryonic fibroblasts (HCoV-229E-37)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory