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Targeted Allele Detail
Symbol: Stat1tm1Dlv
Name: signal transducer and activator of transcription 1; targeted mutation 1, David E Levy
MGI ID: MGI:1930947
Synonyms: STAT-, Stat1-, STAT1-, Stat1 KO
Gene: Stat1  Location: Chr1:52158599-52201024 bp, + strand  Genetic Position: Chr1, 26.81 cM
Alliance: Stat1tm1Dlv page
Germline Transmission:  Earliest citation of germline transmission: J:31325
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced 5.7 kb of sequence, including 3 exons and a portion of a fourth encoding amino acids 221-365. This allele produces a partial nonfunctional protein product. (J:31325)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Stat1tm1Dlv
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Stat1 Mutation:  52 strains or lines available
Original:  J:31325 Durbin JE, et al., Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell. 1996 Feb 9;84(3):443-50
All:  224 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory