Phenotypes associated with this allele

• Allele Symbol: Rspo3^tm1Arte
• Allele Name: targeted mutation 1, TaconicArtemis
• Allele ID: MGI:5643687
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rspo3^tm1Arte/Rspo3^tm1Arte Isl1^tm1(cre)Sev/Isl1^+	involves: 129 * C57BL/6	MGI:5643693
cn2	Rspo3^tm1Arte/Rspo3^tm1Arte Isl1^tm1(cre)Tmj/Isl1^+	involves: 129X1/SvJ * C57BL/6	MGI:5643692

Genotype
MGI:5643693

cn1

• Allelic Composition: Rspo3^tm1Arte/Rspo3^tm1Arte; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:214093 )

• embryonic lethality at E11.5

cardiovascular system

blood vessel congestion ( J:214093 )

thin myocardium ( J:214093 )

• myocardial wall thickness is diminished at E10

abnormal cardiac outflow tract development ( J:214093 )

• poorly developed outflow tract

abnormal heart right ventricle morphology ( J:214093 )

• poorly developed right ventricle

pericardial edema ( J:214093 )

• in all mice

homeostasis/metabolism

pericardial edema ( J:214093 )

• in all mice

muscle

thin myocardium ( J:214093 )

• myocardial wall thickness is diminished at E10

Genotype
MGI:5643692

cn2

• Allelic Composition: Rspo3^tm1Arte/Rspo3^tm1Arte; Isl1^tm1(cre)Tmj/Isl1⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:214093 )

• late gestational lethality at E14.5-E16.5 in most mice due to cardiovascular failure

cardiovascular system

double outlet right ventricle ( J:214093 )

• all mice exhibit small right ventricle and/or double outlet right ventricle

decreased heart right ventricle size ( J:214093 )

• all mice exhibit small right ventricle and/or double outlet right ventricle

pericardial edema ( J:214093 )

homeostasis/metabolism

pericardial edema ( J:214093 )