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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Med20em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:5643678
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Med20em1(IMPC)J/Med20em1(IMPC)J C57BL/6NJ-Med20em1(IMPC)J/J MGI:5884007
ht2
Med20em1(IMPC)J/Med20+ C57BL/6NJ-Med20em1(IMPC)J/J MGI:5884006


Genotype
MGI:5884007
hm1
Allelic
Composition
Med20em1(IMPC)J/Med20em1(IMPC)J
Genetic
Background
C57BL/6NJ-Med20em1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Med20em1(IMPC)J mutation (1 available); any Med20 mutation (37 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• blastocysts show apparent cell death after 3 days in culture
• cultured blastocysts fail to form a typical outgrowth colony

embryo
• cultured blastocysts fail to form a typical outgrowth colony
• blastocysts fail to hatch from the zona pellucida with apparent cell death after 3 days in culture
• no epiblast cells are observed after 3 days in culture
• no primitive endoderm (PrE) cells are observed after 3 days in culture
• no trophectoderm (TE) is observed after 3 days in culture

mortality/aging
• normal blastocysts are present at lower than expected Mendelian ratios at E3.5 (12% versus 25%); no embryos or excess resorption sites are observed at E7.5




Genotype
MGI:5884006
ht2
Allelic
Composition
Med20em1(IMPC)J/Med20+
Genetic
Background
C57BL/6NJ-Med20em1(IMPC)J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Med20em1(IMPC)J mutation (1 available); any Med20 mutation (37 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system

immune system

nervous system

vision/eye





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory