Phenotypes associated with this allele

• Allele Symbol: Picalm^tm1.2Tmae
• Allele Name: targeted mutation 1.2, Takahiro Maeda
• Allele ID: MGI:5640747
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Picalm^tm1.2Tmae/Picalm^tm1.2Tmae	involves: C57BL/6 * FVB/N	MGI:5640749
ht2	Picalm^tm1.2Tmae/Picalm^+	involves: C57BL/6 * FVB/N	MGI:5640750

Genotype
MGI:5640749

hm1

• Allelic Composition: Picalm^tm1.2Tmae/Picalm^tm1.2Tmae
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:220728 )

• embryos die at late embryonic stages

• loss of homozygous embryos is observed beginning at E14.5

growth/size/body

decreased embryo size ( J:220728 )

hematopoietic system

abnormal erythropoiesis ( J:220728 )

decreased erythroblast number ( J:220728 )

• numbers of mature erythroblasts (R4) found in E14.5 fetal liver are decreased

increased erythroblast number ( J:220728 )

• numbers of immature erythroblasts (R2) found in E14.5 fetal liver are increased

abnormal fetal liver hematopoietic progenitor cell morphology ( J:220728 )

• total fetal liver cell counts are decreased in E14.5 embryos

embryo

decreased embryo size ( J:220728 )

abnormal embryonic tissue morphology ( J:220728 )

• E13.5 embryos are smaller and paler than wild-type

Genotype
MGI:5640750

ht2

• Allelic Composition: Picalm^tm1.2Tmae/Picalm⁺
• Genetic Background: involves: C57BL/6 * FVB/N

hematopoietic system

microcytic anemia ( J:220728 )

• mild microcytic anemia