All Phenotypes Orc6<em1(IMPC)J> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Orc6^em1(IMPC)J/Orc6^em1(IMPC)J	C57BL/6NJ-Orc6^em1(IMPC)J/J	MGI:5884021
ht2	Orc6^em1(IMPC)J/Orc6⁺	C57BL/6NJ-Orc6^em1(IMPC)J/J	MGI:6263076

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased cell death ( J:279207 )

• morulas recovered at E3.5 appear to be dying

• embryos show no further development with apparent cell death after 3 days in culture

embryo

failure of blastocyst formation ( J:279207 )

• embryos fail to reach a morphological blastocyst stage after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in culture, embryos fail to hatch from the zona pellucida with apparent cell death, never reaching a morphological blastocyst stage

abnormal morula morphology ( J:279207 )

• morulas recovered at E3.5 appear to be dying

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at lower than expected Mendelian ratios at E3.5 (14% versus 25%) and appear to arrest/die prior to blastocyst formation; no embryos or excess resorption sites are observed at E7.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Allelic Composition	Orc6^em1(IMPC)J/Orc6⁺
Genetic Background	C57BL/6NJ-Orc6^em1(IMPC)J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Orc6^em1(IMPC)J mutation (1 available); any Orc6 mutation (24 available)

Data Sources

IMPC Data for Orc6

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired pupillary reflex ( J:211773 )

IMPC - JAX

hyperactivity ( J:211773 )

IMPC - JAX

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

IMPC - JAX

vision/eye

impaired pupillary reflex ( J:211773 )

IMPC - JAX

persistence of hyaloid vascular system ( J:211773 )

IMPC - JAX

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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