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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vdac2tm1.1Ehyc
targeted mutation 1.1, Emily HY Cheng
MGI:5638533
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Bak1tm1Thsn/Bak1tm1Thsn
Tg(Lck-cre)1Cwi/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:5691371
cn2
 		Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Tg(Lck-cre)1Cwi/? 		involves: 129X1/SvJ * C57BL/6 * DBA/2 MGI:5691369
cn3
 		Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Baxtm2Sjk/Baxtm2Sjk
Tg(Lck-cre)1Cwi/? 		involves: 129X1/SvJ * C57BL/6 * DBA/2 MGI:5691375


Genotype
MGI:5691371
cn1
Allelic
Composition		 Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Bak1tm1Thsn/Bak1tm1Thsn
Tg(Lck-cre)1Cwi/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Vdac2tm1.1Ehyc mutation (0 available); any Vdac2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:220951 )
N
• thymus size normal
• thymocyte number normal
• no increase in apoptosis




Genotype
MGI:5691369
cn2
Allelic
Composition		 Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Tg(Lck-cre)1Cwi/?
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)1Cwi mutation (3 available)
Vdac2tm1.1Ehyc mutation (0 available); any Vdac2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal thymocyte apoptosis ( J:220951 )
• BAK from T cells is more sensitive to apoptotic signals
• earlier translocation of cytochrome c out of mitochondria
• earlier caspase activation
• thymocytes cultured with antibody to CD3 die more rapidly
small thymus ( J:220951 )
• further shrinkage of thymus when mice injected with antibody to CD3
decreased thymocyte number ( J:220951 )
• two fold reduction of thymocytes although the developmental profile seems normal
• 90% of double+ thymocytes killed when mice injected with antibody to CD3

cellular
abnormal thymocyte apoptosis ( J:220951 )
• BAK from T cells is more sensitive to apoptotic signals
• earlier translocation of cytochrome c out of mitochondria
• earlier caspase activation
• thymocytes cultured with antibody to CD3 die more rapidly

hematopoietic system
abnormal thymocyte apoptosis ( J:220951 )
• BAK from T cells is more sensitive to apoptotic signals
• earlier translocation of cytochrome c out of mitochondria
• earlier caspase activation
• thymocytes cultured with antibody to CD3 die more rapidly
small thymus ( J:220951 )
• further shrinkage of thymus when mice injected with antibody to CD3
decreased thymocyte number ( J:220951 )
• two fold reduction of thymocytes although the developmental profile seems normal
• 90% of double+ thymocytes killed when mice injected with antibody to CD3

endocrine/exocrine glands
abnormal thymocyte apoptosis ( J:220951 )
• BAK from T cells is more sensitive to apoptotic signals
• earlier translocation of cytochrome c out of mitochondria
• earlier caspase activation
• thymocytes cultured with antibody to CD3 die more rapidly
small thymus ( J:220951 )
• further shrinkage of thymus when mice injected with antibody to CD3
decreased thymocyte number ( J:220951 )
• two fold reduction of thymocytes although the developmental profile seems normal
• 90% of double+ thymocytes killed when mice injected with antibody to CD3




Genotype
MGI:5691375
cn3
Allelic
Composition		 Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Baxtm2Sjk/Baxtm2Sjk
Tg(Lck-cre)1Cwi/?
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Baxtm2Sjk mutation (1 available); any Bax mutation (24 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Vdac2tm1.1Ehyc mutation (0 available); any Vdac2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:220951 )
• two fold reduction of thymocytes although the developmental profile seems normal

hematopoietic system
decreased thymocyte number ( J:220951 )
• two fold reduction of thymocytes although the developmental profile seems normal

endocrine/exocrine glands
decreased thymocyte number ( J:220951 )
• two fold reduction of thymocytes although the developmental profile seems normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory