Analysis Tools
immune system
| N |
• thymus size normal
• thymocyte number normal
• no increase in apoptosis
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Allele Symbol Allele Name Allele ID |
Vdac2tm1.1Ehyc targeted mutation 1.1, Emily HY Cheng MGI:5638533 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• thymus size normal
• thymocyte number normal
• no increase in apoptosis
|
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• BAK from T cells is more sensitive to apoptotic signals
• earlier translocation of cytochrome c out of mitochondria
• earlier caspase activation
• thymocytes cultured with antibody to CD3 die more rapidly
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• further shrinkage of thymus when mice injected with antibody to CD3
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• two fold reduction of thymocytes although the developmental profile seems normal
• 90% of double+ thymocytes killed when mice injected with antibody to CD3
|
|
• BAK from T cells is more sensitive to apoptotic signals
• earlier translocation of cytochrome c out of mitochondria
• earlier caspase activation
• thymocytes cultured with antibody to CD3 die more rapidly
|
|
• BAK from T cells is more sensitive to apoptotic signals
• earlier translocation of cytochrome c out of mitochondria
• earlier caspase activation
• thymocytes cultured with antibody to CD3 die more rapidly
|
|
• further shrinkage of thymus when mice injected with antibody to CD3
|
|
• two fold reduction of thymocytes although the developmental profile seems normal
• 90% of double+ thymocytes killed when mice injected with antibody to CD3
|
|
• BAK from T cells is more sensitive to apoptotic signals
• earlier translocation of cytochrome c out of mitochondria
• earlier caspase activation
• thymocytes cultured with antibody to CD3 die more rapidly
|
|
• further shrinkage of thymus when mice injected with antibody to CD3
|
|
• two fold reduction of thymocytes although the developmental profile seems normal
• 90% of double+ thymocytes killed when mice injected with antibody to CD3
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• two fold reduction of thymocytes although the developmental profile seems normal
|
|
• two fold reduction of thymocytes although the developmental profile seems normal
|
|
• two fold reduction of thymocytes although the developmental profile seems normal
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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