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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apptm2.1Tcs
targeted mutation 2.1, Takaomi C Saido
MGI:5637816
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Apptm2.1Tcs/Apptm2.1Tcs involves: C57BL/6 MGI:5638672
cx2
Apptm2.1Tcs/Apptm2.1Tcs
Casttm1Tcs/Casttm1Tcs
involves: 129P2/OlaHsd * C57BL/6 MGI:5638676


Genotype
MGI:5638672
hm1
Allelic
Composition
Apptm2.1Tcs/Apptm2.1Tcs
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm2.1Tcs mutation (3 available); any App mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show impaired memory in the Y-maze test at 18 months of age

homeostasis/metabolism
• mice exhibit cortical amyloidosis after 6 months of age
• mice produce more amyloid beta42 than controls, which increase with age and progressive amyloid beta pathology
• the ratio of amyloid beta42 to amyloid beta40 is increased
• initial amyloid beta deposition is seen at 6 months of age
• amyloid beta1-42 appears initially, followed by amyloid beta3(pE)-42 and amyloid betaX-40 is a minor species

hematopoietic system
• accumulation of microglia, a sign of neuroinflammation, around the amyloid beta plaques

immune system
• accumulation of microglia, a sign of neuroinflammation, around the amyloid beta plaques

nervous system
• accumulation of microglia, a sign of neuroinflammation, around the amyloid beta plaques
• mice produce more amyloid beta42 than controls, which increase with age and progressive amyloid beta pathology
• the ratio of amyloid beta42 to amyloid beta40 is increased
• initial amyloid beta deposition is seen at 6 months of age
• amyloid beta1-42 appears initially, followed by amyloid beta3(pE)-42 and amyloid betaX-40 is a minor species
• accumulation of activated astrocytes, a sign of neuroinflammation, around the amyloid beta plaques
• synaptic alternations as indicated by loss of synaptophysin and PSD95 immunoreactivity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:212758




Genotype
MGI:5638676
cx2
Allelic
Composition
Apptm2.1Tcs/Apptm2.1Tcs
Casttm1Tcs/Casttm1Tcs
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm2.1Tcs mutation (3 available); any App mutation (69 available)
Casttm1Tcs mutation (1 available); any Cast mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit an increase in memory impairment in the Y-maze test by 3 months compared to single APPtm2.1Tcs homozygotes

hematopoietic system
• microgliosis is increased compared to single APPtm2.1Tcs homozygotes

homeostasis/metabolism
• amyloid beta amyloidosis is exacerbated compared to single APPtm2.1Tcs homozygotes

immune system
• microgliosis is increased compared to single APPtm2.1Tcs homozygotes

nervous system
• microgliosis is increased compared to single APPtm2.1Tcs homozygotes
• astrocytosis is increased compared to single APPtm2.1Tcs homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/12/2023
MGI 6.22
The Jackson Laboratory