Phenotypes associated with this allele

• Allele Symbol: Vwf^{tm3.1(VWF)Diac}
• Allele Name: targeted mutation 3.1, Thomas G Diacovo
• Allele ID: MGI:5637368
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vwf^tm3.1(VWF)Diac/Vwf^tm3.1(VWF)Diac	Not Specified	MGI:5637381

Genotype
MGI:5637381

hm1

• Allelic Composition: Vwf^{tm3.1(VWF)Diac}/Vwf^{tm3.1(VWF)Diac}
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired blood coagulation ( J:220792 )

• mice show a diminished capacity to form thrombi in laser-injured arterioles

• wild-type mouse platelets do not accumulate on surface-immobilized mutant plasma VWF, indicating that plasma VWF cannot support hemostasis and thrombosis

• however, in the presence of human platelets, mice form large and occlusive thrombi in laser-injured arterioles

increased bleeding time ( J:220792 )

• mice show prolonged tail bleeding times