Vwf^{tm3.1(VWF)Diac}
Targeted Allele Detail

Summary

• Symbol: Vwf^{tm3.1(VWF)Diac}
• Name: Von Willebrand factor; targeted mutation 3.1, Thomas G Diacovo
• MGI ID: MGI:5637368
• Synonyms: VWF^HA1
• Gene: Vwf Location: Chr6:125529911-125663642 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Vwf^{tm3.1(VWF)Diac} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220792
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Vwf^{tm3.1(VWF)Diac} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  VWF (7450)

  Vwf	(MGI:98941)

• Mutation details: The majority of murine exon 28 was replaced with the human VWF A1 domain (amino acids 1240P through 1481G). In addition a floxed pGK-Neo cassette was inserted downstream of exon 28 which was removed via cre-mediated excision. (J:220792)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vwf Mutation: 139 strains or lines available

References

• Original: J:220792 Chen J, et al., Exploiting the kinetic interplay between GPIbalpha-VWF binding interfaces to regulate hemostasis and thrombosis. Blood. 2014 Dec 11;124(25):3799-807
• All: 1 reference(s)