Phenotypes associated with this allele

• Allele Symbol: Vwf^tm2.1Diac
• Allele Name: targeted mutation 2.1, Thomas G Diacovo
• Allele ID: MGI:5637366
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vwf^tm2.1Diac/Vwf^tm2.1Diac	Not Specified	MGI:5637379

Genotype
MGI:5637379

hm1

• Allelic Composition: Vwf^tm2.1Diac/Vwf^tm2.1Diac
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:220792 )

N • mice show normal tail bleeding times, normal thrombi formation in laser-injured arterioles, and normal platelet accumulation and translocation velocities on surface-immobilized VWF

impaired blood coagulation ( J:220792 )

• mice show a greater than 50% reduction in thrombus size 20 minutes post-administration of human platelets

increased bleeding time ( J:220792 )

• mice show a 3-fold prolongation in tail bleeding time 20 minutes post-administration of human platelets