Vwf^tm2.1Diac
Targeted Allele Detail

Summary

• Symbol: Vwf^tm2.1Diac
• Name: Von Willebrand factor; targeted mutation 2.1, Thomas G Diacovo
• MGI ID: MGI:5637366
• Synonyms: VWF^{I1309V, R1326H}
• Gene: Vwf Location: Chr6:125529911-125663642 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Vwf^tm2.1Diac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220792
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A guanine to adenine at position 3925 (ATC>GTC) and adenine at position 3977 instead of guanine (CGT>CAT) were introduced in exon 28 to create the I1309V and R1325H mutations. In addition, a floxed pGK-Neo cassette was inserted downstream of exon 28 which was removed via cre-mediated excision. (J:220792)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vwf Mutation: 139 strains or lines available

References

• Original: J:220792 Chen J, et al., Exploiting the kinetic interplay between GPIbalpha-VWF binding interfaces to regulate hemostasis and thrombosis. Blood. 2014 Dec 11;124(25):3799-807
• All: 1 reference(s)