Phenotypes associated with this allele

• Allele Symbol: Nsd3^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5637114
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nsd3^tm1b(EUCOMM)Hmgu/Nsd3^tm1b(EUCOMM)Hmgu	C57BL/6N-Nsd3^tm1b(EUCOMM)Hmgu/H	MGI:5757888
ht2	Nsd3^tm1b(EUCOMM)Hmgu/Nsd3^+	C57BL/6N-Nsd3^tm1b(EUCOMM)Hmgu/H	MGI:5757887

Genotype
MGI:5757888

hm1

• Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0563_4_G02

Data Sources

IMPC Data for Nsd3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - HAR

increased startle reflex ( J:211773 )

♂

IMPC - HAR

craniofacial

abnormal snout morphology ( J:211773 )

IMPC - HAR

growth/size/body

abnormal snout morphology ( J:211773 )

IMPC - HAR

hematopoietic system

small spleen ( J:211773 )

♂

IMPC - HAR

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - HAR

immune system

small spleen ( J:211773 )

♂

IMPC - HAR

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:5757887

ht2

• Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3⁺
• Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0563_4_G02

Data Sources

IMPC Data for Nsd3

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - HAR

behavior/neurological

tremors ( J:211773 )

IMPC - HAR

trunk curl ( J:211773 )

♀

IMPC - HAR