Phenotypes associated with this allele

• Allele Symbol: Pierce1^{tm2b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 2b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5637039
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pierce1^tm2b(EUCOMM)Wtsi/Pierce1^tm2b(EUCOMM)Wtsi	C57BL/6N-Pierce1^tm2b(EUCOMM)Wtsi/Wtsi	MGI:5756622
hm2	Pierce1^tm2b(EUCOMM)Wtsi/Pierce1^tm2b(EUCOMM)Wtsi	involves: C57BL/6N	MGI:6849738
cx3	Pierce1^tm2b(EUCOMM)Wtsi/Pierce1^tm2b(EUCOMM)Wtsi Pierce2^em1(IMPC)H/Pierce2^em1(IMPC)H	involves: C57BL/6N	MGI:6849740
cx4	Pierce1^tm2b(EUCOMM)Wtsi/Pierce1^tm2b(EUCOMM)Wtsi Pierce2^em1(IMPC)H/Pierce2^+	involves: C57BL/6N	MGI:6849741

Genotype
MGI:5756622

hm1

• Allelic Composition: Pierce1^{tm2b(EUCOMM)Wtsi}/Pierce1^{tm2b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Pierce1^{tm2b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0968_5_H07

Data Sources

IMPC Data for Pierce1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased grip strength ( J:211773 )

♀

IMPC - WTSI

cardiovascular system

absent segment of posterior cerebral artery ( J:239583 )

DMDD

abnormal vertebral artery topology ( J:239583 )

DMDD

muscular ventricular septal defect ( J:239583 )

DMDD

abnormal aortic valve cusp morphology ( J:239583 )

DMDD

growth/size/body

heterochrony ( J:239583 )

DMDD

situs inversus totalis ( J:239583 )

DMDD

homeostasis/metabolism

retropleural edema ( J:239583 )

DMDD

immune system

blood in lymph vessels ( J:239583 )

DMDD

nervous system

absent segment of posterior cerebral artery ( J:239583 )

DMDD

normal phenotype

no abnormal phenotype detected ( J:239583 )

DMDD

Genotype
MGI:6849738

hm2

• Allelic Composition: Pierce1^{tm2b(EUCOMM)Wtsi}/Pierce1^{tm2b(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N

mortality/aging

prenatal lethality, incomplete penetrance ( J:316131 )

• fewer than expected mice are born

embryo

abnormal motile primary cilium physiology ( J:316131 )

• reduced beating frequency

growth/size/body

situs ambiguus ( J:316131 )

• in some mice

situs inversus ( J:316131 )

• in some mice

respiratory system

abnormal respiratory motile cilium physiology ( J:316131 )

• modestly reduced tracheal cilia beating frequency

cellular

abnormal motile primary cilium physiology ( J:316131 )

• reduced beating frequency

abnormal respiratory motile cilium physiology ( J:316131 )

• modestly reduced tracheal cilia beating frequency

Genotype
MGI:6849740

cx3

• Allelic Composition: Pierce1^{tm2b(EUCOMM)Wtsi}/Pierce1^{tm2b(EUCOMM)Wtsi}; Pierce2^em1(IMPC)H/Pierce2^em1(IMPC)H
• Genetic Background: involves: C57BL/6N

mortality/aging

postnatal lethality, complete penetrance ( J:316131 )

• few surviving mice die by P20

prenatal lethality, incomplete penetrance ( J:316131 )

• fewer than expected mice are born

growth/size/body

situs ambiguus ( J:316131 )

• in some mice

situs inversus ( J:316131 )

• in most mice

nervous system

hydrocephaly ( J:316131 )

Genotype
MGI:6849741

cx4

• Allelic Composition: Pierce1^{tm2b(EUCOMM)Wtsi}/Pierce1^{tm2b(EUCOMM)Wtsi}; Pierce2^em1(IMPC)H/Pierce2⁺
• Genetic Background: involves: C57BL/6N

growth/size/body

situs ambiguus ( J:316131 )

• in some mice

situs inversus ( J:316131 )

• in some mice