Phenotypes associated with this allele

• Allele Symbol: Cnot4^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5636993
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnot4^tm1b(EUCOMM)Wtsi/Cnot4^tm1b(EUCOMM)Wtsi	C57BL/6N-Cnot4^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5767606
ht2	Cnot4^tm1b(EUCOMM)Wtsi/Cnot4^+	C57BL/6N-Cnot4^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5797442

Genotype
MGI:5767606

hm1

• Allelic Composition: Cnot4^{tm1b(EUCOMM)Wtsi}/Cnot4^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Cnot4^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0682_3_G11

Data Sources

IMPC Data for Cnot4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal chorion morphology ( J:261316 )

• unpatterned chorion at E9.5

abnormal placenta morphology ( J:261316 )

• branching morphology defect at E9.5

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

lethality throughout fetal growth and development, complete penetrance ( J:261316 )

• complete lethality at E14.5

Genotype
MGI:5797442

ht2

• Allelic Composition: Cnot4^{tm1b(EUCOMM)Wtsi}/Cnot4⁺
• Genetic Background: C57BL/6N-Cnot4^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0682_3_G11

Data Sources

IMPC Data for Cnot4

adipose tissue

increased total body fat amount ( J:211773 )

♀

IMPC - WTSI

growth/size/body

decreased lean body mass ( J:211773 )

♀

IMPC - WTSI

decreased body length ( J:211773 )

IMPC - WTSI

hematopoietic system

decreased KLRG1-positive NK cell number ( J:211773 )

♂

IMPC - WTSI

homeostasis/metabolism

decreased circulating alkaline phosphatase level ( J:211773 )

♂

IMPC - WTSI

immune system

decreased KLRG1-positive NK cell number ( J:211773 )

♂

IMPC - WTSI

integument

abnormal epidermal immune compartment ( J:211773 )

IMPC - WTSI

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - WTSI

decreased bone mineral content ( J:211773 )

♀

IMPC - WTSI