Phenotypes associated with this allele

• Allele Symbol: Nrxn1^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5636923
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nrxn1^tm1b(KOMP)Wtsi/Nrxn1^tm1b(KOMP)Wtsi	C57BL/6N-Nrxn1^tm1b(KOMP)Wtsi/H	MGI:5757433
ht2	Nrxn1^tm1b(KOMP)Wtsi/Nrxn1^+	C57BL/6N-Nrxn1^tm1b(KOMP)Wtsi/H	MGI:5797687

Genotype
MGI:5757433

hm1

• Allelic Composition: Nrxn1^{tm1b(KOMP)Wtsi}/Nrxn1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Nrxn1^{tm1b(KOMP)Wtsi}/H
• Cell Lines: EPD0796_5_E08

Data Sources

IMPC Data for Nrxn1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

♂

IMPC - HAR

behavior/neurological

tremors ( J:211773 )

IMPC - HAR

decreased grip strength ( J:211773 )

IMPC - HAR

hematopoietic system

increased red blood cell distribution width ( J:211773 )

♂

IMPC - HAR

increased neutrophil cell number ( J:211773 )

♂

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - HAR

increased monocyte cell number ( J:211773 )

♂

IMPC - HAR

homeostasis/metabolism

decreased fasting circulating glucose level ( J:211773 )

♀

IMPC - HAR

decreased circulating cholesterol level ( J:211773 )

♂

IMPC - HAR

decreased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - HAR

decreased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - HAR

increased circulating aspartate transaminase level ( J:211773 )

IMPC - HAR

decreased circulating serum albumin level ( J:211773 )

♂

IMPC - HAR

decreased circulating total protein level ( J:211773 )

♂

IMPC - HAR

impaired glucose tolerance ( J:211773 )

IMPC - HAR

immune system

increased neutrophil cell number ( J:211773 )

♂

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - HAR

increased monocyte cell number ( J:211773 )

♂

IMPC - HAR

respiratory system

decreased pulmonary respiratory rate ( J:211773 )

♀

IMPC - HAR

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - HAR

Genotype
MGI:5797687

ht2

• Allelic Composition: Nrxn1^{tm1b(KOMP)Wtsi}/Nrxn1⁺
• Genetic Background: C57BL/6N-Nrxn1^{tm1b(KOMP)Wtsi}/H
• Cell Lines: EPD0796_5_E08

Data Sources

IMPC Data for Nrxn1

behavior/neurological

tremors ( J:211773 )

IMPC - HAR

growth/size/body

increased lean body mass ( J:211773 )

♂

IMPC - HAR

hematopoietic system

increased neutrophil cell number ( J:211773 )

♂

IMPC - HAR

homeostasis/metabolism

increased circulating amylase level ( J:211773 )

♂

IMPC - HAR

immune system

increased neutrophil cell number ( J:211773 )

♂

IMPC - HAR