All Phenotypes Gt(ROSA)26Sor<tm1(GRN)Pvd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^tm1(GRN)Pvd
targeted mutation 1, Philip Van Damme
MGI:5636723

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(GRN)Pvd/Gt(ROSA)26Sor⁺ Tg(Pgk1-cre)1Lni/0 Tg(SOD1*G93A)1Gur/0	B6J.Cg-Tg(Pgk1-cre)1Lni Gt(ROSA)26Sor^tm1(GRN)Pvd Tg(SOD1*G93A)1Gur	MGI:5637745
cn2	Gt(ROSA)26Sor^tm1(GRN)Pvd/Gt(ROSA)26Sor^tm1(GRN)Pvd Tg(Pgk1-cre)1Lni/0 Tg(SOD1*G93A)1Gur/0	B6J.Cg-Tg(Pgk1-cre)1Lni Gt(ROSA)26Sor^tm1(GRN)Pvd Tg(SOD1*G93A)1Gur	MGI:5637746

Allelic Composition	Gt(ROSA)26Sor^tm1(GRN)Pvd/Gt(ROSA)26Sor⁺ Tg(Pgk1-cre)1Lni/0 Tg(SOD1*G93A)1Gur/0
Genetic Background	B6J.Cg-Tg(Pgk1-cre)1Lni Gt(ROSA)26Sor^tm1(GRN)Pvd Tg(SOD1*G93A)1Gur

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(GRN)Pvd mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Pgk1-cre)1Lni mutation (1 available)
Tg(SOD1*G93A)1Gur mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:211734 )

• average lifespan is 163.3 days

nervous system

motor neuron degeneration ( J:211734 )

• onset or progression of motor neuron degeneration is similar to that seen in mice expressing only Tg(SOD1*G93A)1Gur, with an average onset of disease at 134.2 days

behavior/neurological

impaired coordination ( J:211734 )

• mice show impaired performance on the rotarod and in hanging from a grid to a similar extent as seen in mice expressing only Tg(SOD1*G93A)1Gur

Allelic Composition	Gt(ROSA)26Sor^tm1(GRN)Pvd/Gt(ROSA)26Sor^tm1(GRN)Pvd Tg(Pgk1-cre)1Lni/0 Tg(SOD1*G93A)1Gur/0
Genetic Background	B6J.Cg-Tg(Pgk1-cre)1Lni Gt(ROSA)26Sor^tm1(GRN)Pvd Tg(SOD1*G93A)1Gur