Phenotypes associated with this allele

• Allele Symbol: Gzmk^tm1.1Pib
• Allele Name: targeted mutation 1.1, Phillip I Bird
• Allele ID: MGI:5636646
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gzmk^tm1.1Pib/Gzmk^tm1.1Pib	B6(Cg)-Gzmk^tm1.1Pib	MGI:6507744

Genotype
MGI:6507744

hm1

• Allelic Composition: Gzmk^tm1.1Pib/Gzmk^tm1.1Pib
• Genetic Background: B6(Cg)-Gzmk^tm1.1Pib

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:302067 )

N • mice are healthy, anatomically normal and show no alterations in the WBC count, lymphocytes, RBC count, platelets or splenocytes, indicating normal T-cell development and homeostasis

immune system

immune system phenotype ( J:302067 )

N • mice exhibit normal viral clearance and disease progression in response to i.p. infection with lymphocytic choriomeningitis virus (LCMV) strain WE , with no differences in weight or temperature over 12 days of infection, viral titers (in liver or spleen), numbers of T cells, B cells or NK cells or in the proportion of LCMV-specific CD8+ T cells at day 8 post-infection relative to wild-type controls

N • mice exhibit normal viral clearance and disease progression in response to s.c. infection with mouse pox Ectromelia virus Moscow strain relative to wild-type controls

N • ex vivo, LCMV-specific CTL show normal apoptosis induction in EL4 target cells displaying a viral peptide, indicating normal cytotoxicity