Gzmk^tm1.1Pib
Targeted Allele Detail

Summary

• Symbol: Gzmk^tm1.1Pib
• Name: granzyme K; targeted mutation 1.1, Phillip I Bird
• MGI ID: MGI:5636646
• Synonyms: Gzmk^-
• Gene: Gzmk Location: Chr13:113308164-113317499 bp, - strand Genetic Position: Chr13, 63.93 cM
• Alliance: Gzmk^tm1.1Pib page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302067
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 5 were replaced with a loxP-flanked neomycin selection cassette. The selection cassette was removed via Cre-mediated recombination in the germline. RT-PCR and flow cytometry analysis confirmed the absence of gene products in activated CD8+ T cells from lymphocytic choriomeningitis virus (LCMV)-infected mice. (J:302067)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gzmk Mutation: 24 strains or lines available

References

• Original: J:302067 Joeckel LT, et al., Granzyme K-deficient mice show no evidence of impaired antiviral immunity. Immunol Cell Biol. 2017 Sep;95(8):676-683
• All: 2 reference(s)