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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mzb1tm1.1Rug
targeted mutation 1.1, Rudolf Grosschedl
MGI:5636601
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Blnktm1Pjln/Blnktm1Pjln
Cd79atm1(cre)Reth/Cd79atm1(cre)Reth
Mzb1tm1.1Rug/Mzb1tm1.1Rug 		involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL MGI:6294907
cn2
 		Cd79atm1(cre)Reth/Cd79atm1(cre)Reth
Mzb1tm1.1Rug/Mzb1tm1.1Rug 		involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL MGI:6294908


Genotype
MGI:6294907
cn1
Allelic
Composition		 Blnktm1Pjln/Blnktm1Pjln
Cd79atm1(cre)Reth/Cd79atm1(cre)Reth
Mzb1tm1.1Rug/Mzb1tm1.1Rug
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation (0 available); any Blnk mutation (76 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
Mzb1tm1.1Rug mutation (0 available); any Mzb1 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell physiology ( J:211639 )
• 2.5-fold reduction in frequency of muHC+ lambda5+ cells in bone marrow
• increase in lambda5+ only bone marrow cells




Genotype
MGI:6294908
cn2
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79atm1(cre)Reth
Mzb1tm1.1Rug/Mzb1tm1.1Rug
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
Mzb1tm1.1Rug mutation (0 available); any Mzb1 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased pro-B cell number ( J:211639 )
• increased percentage of B220+ CD43+ pro-B cells in bone marrow
increased late pro-B cell number ( J:211639 )
• increased percentage of B220+ CD19+ muHC- CD25- late pro-B cells in bone marrow
abnormal B cell number ( J:211639 )
• decrease in CD19+ B cells in splenic B cell compartment
• reduced frequency of peritoneal B cells
• reduced percentage of B220hi CD43- recirculating B cells in bone marrow
• reduced percentage of B220int CD43- pre-B cells in bone marrow
• reduced number of muHC+ cells in IL7+ bone marrow B cell cultures
• normal frequency of cells with intracellular muHC in IL7+ bone marrow B cell cultures
decreased pre-B cell number ( J:211639 )
• reduced CD25+ pre-B cell number in bone marrow

immune system
increased pro-B cell number ( J:211639 )
• increased percentage of B220+ CD43+ pro-B cells in bone marrow
increased late pro-B cell number ( J:211639 )
• increased percentage of B220+ CD19+ muHC- CD25- late pro-B cells in bone marrow
abnormal B cell number ( J:211639 )
• decrease in CD19+ B cells in splenic B cell compartment
• reduced frequency of peritoneal B cells
• reduced percentage of B220hi CD43- recirculating B cells in bone marrow
• reduced percentage of B220int CD43- pre-B cells in bone marrow
• reduced number of muHC+ cells in IL7+ bone marrow B cell cultures
• normal frequency of cells with intracellular muHC in IL7+ bone marrow B cell cultures
decreased pre-B cell number ( J:211639 )
• reduced CD25+ pre-B cell number in bone marrow




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory