Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Idh1tm3Mak mutation
(0 available);
any
Idh1 mutation
(42 available)
Tg(Col2a1-cre/ERT2)1Dic mutation
(0 available)
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skeleton
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• mice injected with tamoxifen at 4 weeks of age for 10 doses exhibit knees with multiple enchondroma-like cartilage lesions adjacent to the growth plates; 4-8 cartilage lesions are seen in the growth plates of each knee
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Idh1tm3Mak mutation
(0 available);
any
Idh1 mutation
(42 available)
Tg(Col2a1-cre)1Bhr mutation
(3 available)
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mortality/aging
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• mice that survive after birth die before weaning
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• pups are rarely found alive after birth
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growth/size/body
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• pectus excavatum characterized by a caved-in or sunken appearance of the chest and dysplasia of tracheal cartilage
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respiratory system
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• dysplasia of tracheal cartilage
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skeleton
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• cartilaginous dysplasia of the long bones, ribs, and tracheal cartilage
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• dysplasia of tracheal cartilage
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• disruption of columnar structure of proliferative chondrocytes, especially in the middle of the growth plate
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• tibia shows reduced cartilage mineralization
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Analysis Tools