Idh1^tm3Mak
Targeted Allele Detail

Summary

• Symbol: Idh1^tm3Mak
• Name: isocitrate dehydrogenase 1 (NADP+), soluble; targeted mutation 3, Tak Mak
• MGI ID: MGI:5635887
• Gene: Idh1 Location: Chr1:65197775-65225638 bp, - strand Genetic Position: Chr1, 32.91 cM
• Alliance: Idh1^tm3Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220318
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Single point mutation
• Mutation details: A floxed neo/STOP cassette was inserted upstream of a modified exon 4 in which nucleotide substitution results in the amino acid substitution of glutamine for arginine at position 132 (R132Q). (J:220318)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Idh1 Mutation: 42 strains or lines available

References

• Original: J:220318 Hirata M, et al., Mutant IDH is sufficient to initiate enchondromatosis in mice. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2829-34
• All: 2 reference(s)