About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CAG-RFP/EGFP/Map1lc3b)1Hill
transgene insertion 1, Joseph Hill
MGI:5635828
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fyco1tm1.1Arte/Fyco1tm1.1Arte
Tg(CAG-RFP/EGFP/Map1lc3b)1Hill/0
Tg(Prm-cre)58Og/0 		involves: 129S/Sv * C57BL/6J * C57BL/6N * C57BL/6NTac MGI:7531479
cx2
 		Lamp2tm1Psa/Lamp2tm1Psa
Tg(CAG-RFP/EGFP/Map1lc3b)1Hill/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:6259614
cx3
 		Fyco1tm1.2Arte/Fyco1tm1.2Arte
Tg(CAG-RFP/EGFP/Map1lc3b)1Hill/0 		involves: C57BL/6J * C57BL/6N * C57BL/6NTac * FVB/N MGI:7531476


Genotype
MGI:7531479
cn1
Allelic
Composition		 Fyco1tm1.1Arte/Fyco1tm1.1Arte
Tg(CAG-RFP/EGFP/Map1lc3b)1Hill/0
Tg(Prm-cre)58Og/0
Genetic
Background		 involves: 129S/Sv * C57BL/6J * C57BL/6N * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fyco1tm1.1Arte mutation (0 available); any Fyco1 mutation (44 available)
Tg(CAG-RFP/EGFP/Map1lc3b)1Hill mutation (1 available)
Tg(Prm-cre)58Og mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
impaired autophagy ( J:336796 )
• multiphoton laser scanning microscopy showed a 1.3- and 1.6-fold higher GFP intensity in the whole lens and the anterior lens including lens epithelium, respectively, indicating a reduced autophagic flux in mouse lenses

homeostasis/metabolism
impaired autophagy ( J:336796 )
• multiphoton laser scanning microscopy showed a 1.3- and 1.6-fold higher GFP intensity in the whole lens and the anterior lens including lens epithelium, respectively, indicating a reduced autophagic flux in mouse lenses




Genotype
MGI:6259614
cx2
Allelic
Composition		 Lamp2tm1Psa/Lamp2tm1Psa
Tg(CAG-RFP/EGFP/Map1lc3b)1Hill/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamp2tm1Psa mutation (0 available); any Lamp2 mutation (11 available)
Tg(CAG-RFP/EGFP/Map1lc3b)1Hill mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardial fiber physiology ( J:253728 )
• cardiomyocytes exhibit an accumulation of early autophagosomes and are almost devoid of late autolysosomes, indicating a failure in autophagosome-lysosome fusion




Genotype
MGI:7531476
cx3
Allelic
Composition		 Fyco1tm1.2Arte/Fyco1tm1.2Arte
Tg(CAG-RFP/EGFP/Map1lc3b)1Hill/0
Genetic
Background		 involves: C57BL/6J * C57BL/6N * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fyco1tm1.2Arte mutation (0 available); any Fyco1 mutation (44 available)
Tg(CAG-RFP/EGFP/Map1lc3b)1Hill mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
impaired autophagy ( J:336796 )
• multiphoton laser scanning microscopy showed a 1.3- and 1.6-fold higher GFP intensity in the whole lens and the anterior lens including lens epithelium, respectively, indicating a reduced autophagic flux in mouse lenses

homeostasis/metabolism
impaired autophagy ( J:336796 )
• multiphoton laser scanning microscopy showed a 1.3- and 1.6-fold higher GFP intensity in the whole lens and the anterior lens including lens epithelium, respectively, indicating a reduced autophagic flux in mouse lenses




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory