Phenotypes associated with this allele

• Allele Symbol: Ffar4^tm1.1Mbj
• Allele Name: targeted mutation 1.1, Mikael Bjursell
• Allele ID: MGI:5635615
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ffar4^tm1.1Mbj/Ffar4^tm1.1Mbj	involves: C57BL/6	MGI:5779856

Genotype
MGI:5779856

hm1

• Allelic Composition: Ffar4^tm1.1Mbj/Ffar4^tm1.1Mbj
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal insulin secretion ( J:211675 )

• in the presence of 16.6 mmol/l glucose, DHA (an n-3 fatty acid, 50 or 100 umol/l) fails to increase insulin secretion from mutant islets in a dose-dependent manner, unlike in similarly treated wild-type islets

abnormal pancreatic somatostatin secretion ( J:211675 )

• although mice respond normally to glucose with a 2- to 3-fold increase in somatostatin secretion when the glucose concentration is raised from 3 to 16.6 mmol/l, the GPR120 agonist Metabolex 36 (10 or 30 umol/l) fails to inhibit glucose-induced somatostatin secretion from mutant islets in the presence of 16.6 mmol/l glucose, unlike in similarly treated wild-type islets

• in contrast to Metabolex 36, docosahexaenoic acid (DHA, 50 or 100 umol/l)) fails to attenuate glucose-induced somatostatin secretion from both wild-type and mutant islets in the presence of 16.6 mmol/l glucose

homeostasis/metabolism

abnormal insulin secretion ( J:211675 )

• in the presence of 16.6 mmol/l glucose, DHA (an n-3 fatty acid, 50 or 100 umol/l) fails to increase insulin secretion from mutant islets in a dose-dependent manner, unlike in similarly treated wild-type islets