Phenotypes associated with this allele

• Allele Symbol: Serpina3n^tm1.2Lbrl
• Allele Name: targeted mutation 1.2,
• Allele ID: MGI:5635504
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Serpina3n^tm1.2Lbrl/Serpina3n^tm1.2Lbrl	involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N	MGI:6380699

Genotype
MGI:6380699

hm1

• Allelic Composition: Serpina3n^tm1.2Lbrl/Serpina3n^tm1.2Lbrl
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hyperresponsive to tactile stimuli ( J:220590 )

• responses to a brush stimulus applied to the plantar surface are stronger post spared nerve injury than in wild-type mice

allodynia ( J:220590 )

• mechanical allodynia is increased for up to 7 days after spared nerve injury, but not later

• however, nociceptive responses to acetone and pinprick after nerve injury are not affected

• however, mice show normal basal nociceptive behavior elicited by von Frey mechanical stimulation, plantar application of acetone (cold stimulus), noxious heat, or plantar pinprick stimulation

homeostasis/metabolism

abnormal response to injury ( J:220590 )

• mechanical allodynia is increased for up to 7 days after spared nerve injury, but not later