Serpina3n^tm1.2Lbrl
Targeted Allele Detail

Summary

• Symbol: Serpina3n^tm1.2Lbrl
• Name: serine (or cysteine) peptidase inhibitor, clade A, member 3N; targeted mutation 1.2,
• MGI ID: MGI:5635504
• Gene: Serpina3n Location: Chr12:104372988-104380588 bp, + strand Genetic Position: Chr12, 54.17 cM, cytoband F1
• Alliance: Serpina3n^tm1.2Lbrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220590
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 2, and a frt-flanked neomycin resistance (neo) cassette followed by a second loxP site downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2. (J:220590)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpina3n Mutation: 33 strains or lines available

References

• Original: J:220590 Vicuna L, et al., The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med. 2015 May;21(5):518-23
• All: 1 reference(s)