Phenotypes associated with this allele

• Allele Symbol: Tfap2b^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5635165
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tfap2b^tm1b(EUCOMM)Wtsi/Tfap2b^tm1b(EUCOMM)Wtsi	C57BL/6N-Tfap2b^tm1b(EUCOMM)Wtsi/Ieg	MGI:6263673
ht2	Tfap2b^tm1b(EUCOMM)Wtsi/Tfap2b^+	C57BL/6N-Tfap2b^tm1b(EUCOMM)Wtsi/Ieg	MGI:6263672
ht3	Tfap2b^tm1b(EUCOMM)Wtsi/Tfap2b^+	involves: C57BL/6N * DBA/2	MGI:7627369

Genotype
MGI:6263673

hm1

• Allelic Composition: Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Tfap2b^{tm1b(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0764_4_A09

Data Sources

IMPC Data for Tfap2b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:6263672

ht2

• Allelic Composition: Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b⁺
• Genetic Background: C57BL/6N-Tfap2b^{tm1b(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0764_4_A09

Data Sources

IMPC Data for Tfap2b

behavior/neurological

increased grip strength ( J:211773 )

♂

IMPC - HMGU

nervous system

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

vision/eye

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

iris synechia ( J:211773 )

IMPC - HMGU

Genotype
MGI:7627369

ht3

• Allelic Composition: Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b⁺
• Genetic Background: involves: C57BL/6N * DBA/2

behavior/neurological

behavior/neurological phenotype ( J:297685 )

♂N • normal total time spent in wakefulness, NREM sleep or REM sleep

♂N • normal number of wakefulness and NREM sleep episodes

abnormal circadian sleep/wake cycle ( J:297685 )

♀ • increased wakefulness in dark phase

♀ • normal total time spent in REM sleep across light and dark phases

♀ • normal NREM sleep during dark phase

abnormal non-rapid eye movement sleep pattern ( J:297685 )

♀ • reduced NREM sleep during light phase