All Phenotypes Tfap2b<tm1b(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tfap2b^{tm1b(EUCOMM)Wtsi}
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:5635165

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b^{tm1b(EUCOMM)Wtsi}	C57BL/6N-Tfap2b^{tm1b(EUCOMM)Wtsi}/Ieg	MGI:6263673
ht2	Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b⁺	C57BL/6N-Tfap2b^{tm1b(EUCOMM)Wtsi}/Ieg	MGI:6263672
ht3	Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b⁺	involves: C57BL/6N * DBA/2	MGI:7627369

Allelic Composition	Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b^{tm1b(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Tfap2b^{tm1b(EUCOMM)Wtsi}/Ieg
Cell Lines	EPD0764_4_A09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2b^{tm1b(EUCOMM)Wtsi} mutation (1 available); any Tfap2b mutation (29 available)

Data Sources

IMPC Data for Tfap2b

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Allelic Composition	Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b⁺
Genetic Background	C57BL/6N-Tfap2b^{tm1b(EUCOMM)Wtsi}/Ieg
Cell Lines	EPD0764_4_A09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2b^{tm1b(EUCOMM)Wtsi} mutation (1 available); any Tfap2b mutation (29 available)

Data Sources

IMPC Data for Tfap2b

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased grip strength ( J:211773 )

IMPC - HMGU

nervous system

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

vision/eye

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

iris synechia ( J:211773 )

IMPC - HMGU

cornea deposits ( J:211773 )

IMPC - HMGU

Allelic Composition	Tfap2b^{tm1b(EUCOMM)Wtsi}/Tfap2b⁺
Genetic Background	involves: C57BL/6N * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2b^{tm1b(EUCOMM)Wtsi} mutation (1 available); any Tfap2b mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:297685 )

N	• normal total time spent in wakefulness, NREM sleep or REM sleep • normal number of wakefulness and NREM sleep episodes

abnormal circadian sleep/wake cycle ( J:297685 )

• increased wakefulness in dark phase

• normal total time spent in REM sleep across light and dark phases

• normal NREM sleep during dark phase

abnormal non-rapid eye movement sleep pattern ( J:297685 )

• reduced NREM sleep during light phase

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