Analysis Tools
behavior/neurological
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IMPC - JAX
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IMPC - JAX
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Allele Symbol Allele Name Allele ID |
Amigo1tm1.1(KOMP)Vlcg targeted mutation 1.1, Velocigene MGI:5634962 |
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| Summary |
4 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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IMPC - JAX
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IMPC - JAX
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• at P30, the average density and density recovery profiles of retinal horizontal cells is normal, indicating that horizontal cell mosaics are preserved
• in vivo electroretinographs showed that dark-adapted a- and b-wave amplitudes (reflecting rod and rod bipolar cell responses, respectively) as well as light-adapted b-wave amplitudes (reflecting cone bipolar cell responses to bright stimuli) are normal
• ganglion cell spike trains elicited by dim and bright light stimuli (i.e., the retinal output) are also normal
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• after intravitreal injections of AAV-Grm6-tdTomato, rod bipolar cell dendrites are significantly smaller than in wild-type controls, indicating that changes in horizontal cell axons are matched by changes in synaptic partner dendrites to stabilize retinal function
• however, the density of their connections with rods is normal and rod bipolar cell axon size is unaffected
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• when horizontal cells are sparsely labeled by AAV-CAG-YFP, horizontal cell axons are significantly smaller than in wild-type controls
• however, the densities of horizontal cell axon tips and dendrite clusters as well as the density of axon branches are unaffected
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• after intravitreal injections of AAV-Grm6-tdTomato, rod bipolar cell dendrites are significantly smaller than in wild-type controls, indicating that changes in horizontal cell axons are matched by changes in synaptic partner dendrites to stabilize retinal function
• however, the density of their connections with rods is normal and rod bipolar cell axon size is unaffected
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• when horizontal cells are sparsely labeled by AAV-CAG-YFP, horizontal cell axons are significantly smaller than in wild-type controls
• however, the densities of horizontal cell axon tips and dendrite clusters as well as the density of axon branches are unaffected
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• retinal vibratome slices stained for neurofilament show that developing horizontal cell axons are mistargeted into the outer nuclear layer from P10
• however, rod bipolar cell dendrites do not make the same targeting errors as horizontal cell axons and the stratification patterns of other neurons and ribbon synapses are normal
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• retinal vibratome slices stained for neurofilament show that developing horizontal cell axons are mistargeted into the outer nuclear layer from P10
• however, rod bipolar cell dendrites do not make the same targeting errors as horizontal cell axons and the stratification patterns of other neurons and ribbon synapses are normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• dark-adapted a- and b-wave amplitudes and light-adapted b-wave amplitudes are not significantly different from those in wild-type controls, indicating normal ERG responses
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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