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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rhbdf2M3Btlr
mutation 3, Bruce Beutler
MGI:5632144
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rhbdf2M3Btlr/Rhbdf2M3Btlr C57BL/6J-Rhbdf2M3Btlr MGI:5632145
ht2
 		Rhbdf2M3Btlr/Rhbdf2+ C57BL/6J-Rhbdf2M3Btlr MGI:5632147


Genotype
MGI:5632145
hm1
Allelic
Composition		 Rhbdf2M3Btlr/Rhbdf2M3Btlr
Genetic
Background		 C57BL/6J-Rhbdf2M3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhbdf2M3Btlr mutation (0 available); any Rhbdf2 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:220064 )
• mice with this mutation exhibit reduced TNFalpha secretion in response to the TLR ligands LPS (TLR4), Pam3CSK4 (TLR1/2) and R848 (TLR7/8); secretion is lower in homozygous than in heterozgygous mutant mice.




Genotype
MGI:5632147
ht2
Allelic
Composition		 Rhbdf2M3Btlr/Rhbdf2+
Genetic
Background		 C57BL/6J-Rhbdf2M3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhbdf2M3Btlr mutation (0 available); any Rhbdf2 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:220064 )
• mice with this mutation exhibit reduced TNFalpha secretion in response to the TLR ligands LPS (TLR4), Pam3CSK4 (TLR1/2) and R848 (TLR7/8); secretion in heterozygous mutant mice is intermediate between that in wild-type and homozygous mutant mice.




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory