Rhbdf2^M3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Rhbdf2^M3Btlr
• Name: rhomboid 5 homolog 2; mutation 3, Bruce Beutler
• MGI ID: MGI:5632144
• Synonyms: LosTNF2
• Gene: Rhbdf2 Location: Chr11:116488991-116517786 bp, - strand Genetic Position: Chr11, Syntenic
• Alliance: Rhbdf2^M3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: The mutation is T to A transversion at base pair 116,600,191 (Build 38) on Chromosome 11, or base pair 26,829 in the GenBank genomic region NC_000077, within exon 18 of the gene's 19 exons; this corresponds to nucleotide 2,455 in the mRNA sequence NM_172572. The mutation results in a valine (V) to glutamic acid (E) substitution at amino acid position 645 (V645E) in the protein. (J:220064)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhbdf2 Mutation: 87 strains or lines available

References

• Original: J:220064 Zhang Z, et al., Mutagenetix entry for LosTNF2 (Last updated March 25, 2015). MGI Direct Data Submission. 2015
• All: 1 reference(s)