Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ckmm-cre)5Khn mutation
(4 available)
Yme1l1tm1Tlan mutation
(0 available);
any
Yme1l1 mutation
(59 available)
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homeostasis/metabolism
cardiovascular system
N |
• mice show normal heart function and normal cardiac uptake of glucose
smaller mitochondria in hearts
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mortality/aging
N |
• mice show a normal life span, with a median life span of 125 weeks
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oma1tm1Tlan mutation
(0 available);
any
Oma1 mutation
(23 available)
Tg(Ckmm-cre)5Khn mutation
(4 available)
Yme1l1tm1Tlan mutation
(0 available);
any
Yme1l1 mutation
(59 available)
|
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation
(3 available)
Yme1l1tm1Tlan mutation
(0 available);
any
Yme1l1 mutation
(59 available)
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mortality/aging
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• median lifespan of 46 weeks
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cardiovascular system
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• ongoing cardiomyocyte necrotic cell death
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• hearts show increased endogenous glucose levels and decreased lactate levels
• however, levels of citric acid cycle intermediates are not altered
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• distorted mitochondrial morphology in cardiomyocytes
• mice fed a high-fat diet beginning at 9 weeks of age still contain distorted mitochondria
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• dilated left ventricular chamber
• however, left ventricular mass is preserved
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• progressive heart dysfunction which becomes apparent at 20 weeks
• mice fed a high-fat diet beginning at 9 weeks of age show normal cardiac glucose uptake, normal levels of endogenous cardiac glucose and acylcarnitine, restoration of cardiac function, prevention of cardiac fibrosis, normal exercise tolerance and left ventricular ejection fraction, suppressed heart failure and restored life span
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• dilated cardiomyopathy progresses to heart failure in middle age
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• cardiac glucose uptake is increased
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• reduction in percentage of left ventricular ejection fraction
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growth/size/body
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• weight loss before death
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homeostasis/metabolism
cellular
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• distorted mitochondrial morphology in cardiomyocytes
• mice fed a high-fat diet beginning at 9 weeks of age still contain distorted mitochondria
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• ongoing cardiomyocyte necrotic cell death
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• cardiac glucose uptake is increased
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• smaller mitochondria with normal cristae architecture in hearts
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• specific activities of mitochondrial complexes II, III, and IV are increased in cardiomyocytes
• only moderately impaired ATP synthesis by complex V in hearts
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muscle
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• distorted mitochondrial morphology in cardiomyocytes
• mice fed a high-fat diet beginning at 9 weeks of age still contain distorted mitochondria
|
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• ongoing cardiomyocyte necrotic cell death
|
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• in vitro cardiomyocyte glycolysis rates are increased
• global reduction of total cardiac acylcarnitines, indicating reduced beta oxidation in cardiomyocytes
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• dilated cardiomyopathy progresses to heart failure in middle age
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• cardiac glucose uptake is increased
|
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• reduction in percentage of left ventricular ejection fraction
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oma1tm1Tlan mutation
(0 available);
any
Oma1 mutation
(23 available)
Tg(Myh6-cre)2182Mds mutation
(3 available)
Yme1l1tm1Tlan mutation
(0 available);
any
Yme1l1 mutation
(59 available)
|
|
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cardiovascular system
N |
• mice exhibit normal cardiac function and mitochondrial morphology in hearts, and do not exhibit myocardial fibrosis
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