Phenotypes associated with this allele

• Allele Symbol: Trim28^chatwo
• Allele Name: chatwo
• Allele ID: MGI:5620610
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim28^chatwo/Trim28^chatwo	either: C57BL/6-Trim28^chatwo or (involves: C57BL/6J * FVB/NJ)	MGI:5620614
ht2	Trim28^chatwo/Trim28^tm1.2Ipc	involves: 129S2/SvPas * C57BL/6J	MGI:5620615
cx3	Trim28^chatwo/Trim28^+ Zfp568^chato/Zfp568^+	involves: C57BL/6J	MGI:5620616
cx4	Trim28^chatwo/Trim28^+ Zfp568^chato/Zfp568^chato	involves: C57BL/6J	MGI:5620617
cx5	Trim28^chatwo/Trim28^chatwo Zfp568^chato/Zfp568^+	involves: C57BL/6J	MGI:5620618

Genotype
MGI:5620614

hm1

• Allelic Composition: Trim28^chatwo/Trim28^chatwo
• Genetic Background: either: C57BL/6-Trim28^chatwo or (involves: C57BL/6J * FVB/NJ)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:178936 )

• embryos arrest prior to E9

embryo

abnormal endoderm development ( J:178936 )

• definitive endoderm fails to narrow

short rostral-caudal axis ( J:178936 )

embryonic growth arrest ( J:178936 )

• prior to E9, sometimes at E7.5

• however, embryos are able to gastrulate

abnormal lateral plate mesoderm morphology ( J:178936 )

• shorter and wider than in wild-type mice and located further away from the midline

abnormal somatic mesoderm morphology ( J:178936 )

• mediolaterally expanded

open neural tube ( J:178936 )

abnormal extraembryonic tissue morphology ( J:178936 )

• constricted

abnormal ectoplacental cavity morphology ( J:178936 )

• fails to close

abnormal extraembryonic coelom morphology ( J:178936 )

• reduced

abnormal parietal yolk sac morphology ( J:178936 )

• constricted with numerous bubble-like protrusions

abnormal trophectoderm morphology ( J:178936 )

• the chorionic trophectoderm fails to expand

delayed allantois development ( J:178936 )

• underdeveloped

nervous system

open neural tube ( J:178936 )

digestive/alimentary system

abnormal digestive system development ( J:178936 )

• failure of gut closure

Genotype
MGI:5620615

ht2

• Allelic Composition: Trim28^chatwo/Trim28^tm1.2Ipc
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

mortality/aging

embryonic lethality, complete penetrance ( J:178936 )

• some embryos arrest at E7.5 while others survive until E8.5

embryo

embryonic growth arrest ( J:178936 )

• some embryos arrest at E7.5 while others survive until E8.5

Genotype
MGI:5620616

cx3

• Allelic Composition: Trim28^chatwo/Trim28⁺; Zfp568^chato/Zfp568⁺
• Genetic Background: involves: C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:178936 )

• mice are viable and fertile

Genotype
MGI:5620617

cx4

• Allelic Composition: Trim28^chatwo/Trim28⁺; Zfp568^chato/Zfp568^chato
• Genetic Background: involves: C57BL/6J

embryo

abnormal extraembryonic tissue morphology ( J:178936 )

• similar to Zfp568^chato homozygotes

Genotype
MGI:5620618

cx5

• Allelic Composition: Trim28^chatwo/Trim28^chatwo; Zfp568^chato/Zfp568⁺
• Genetic Background: involves: C57BL/6J

embryo

abnormal extraembryonic tissue morphology ( J:178936 )

• similar to Trim28^chatwo homozygotes