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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Snai3tm1.2Jhws
targeted mutation 1.2, John Weis
MGI:5620192
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Snai3tm1.2Jhws/Snai3tm1.2Jhws involves: 129/Sv * 129S1/Sv MGI:5620193
cx2
 		Snai2tm2Grid/Snai2tm2Grid
Snai3tm1.2Jhws/Snai3tm1.2Jhws 		involves: 129/Sv * 129S1/Sv * C57BL/6 MGI:5620202
cx3
 		Snai2tm2Grid/Snai2+
Snai3tm1.2Jhws/Snai3tm1.2Jhws 		involves: 129/Sv * 129S1/Sv * C57BL/6 MGI:5620264
cx4
 		Snai2tm2Grid/Snai2tm2Grid
Snai3tm1.2Jhws/Snai3+ 		involves: 129/Sv * 129S1/Sv * C57BL/6 MGI:5620265


Genotype
MGI:5620193
hm1
Allelic
Composition		 Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic
Background		 involves: 129/Sv * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai3tm1.2Jhws mutation (0 available); any Snai3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:204710 )
• mice are viable and fertile and display no apparent developmental defects




Genotype
MGI:5620202
cx2
Allelic
Composition		 Snai2tm2Grid/Snai2tm2Grid
Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic
Background		 involves: 129/Sv * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai2tm2Grid mutation (1 available); any Snai2 mutation (34 available)
Snai3tm1.2Jhws mutation (0 available); any Snai3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, incomplete penetrance ( J:204710 )
• approximately 50% fewer homozygotes are produced than expected from heterozygote x heterozygote matings
• fewer homozygote females are produced than expected from heterozygote x heterozygote matings
premature death ( J:204710 )
• few mice survive beyond 15 weeks of age

growth/size/body
decreased body weight ( J:204710 )
• mice are approximately half the size and weight of controls

hematopoietic system
abnormal thymus cortex morphology ( J:204710 )
• altered organization of thymic cortex
abnormal thymus medulla morphology ( J:204710 )
• altered organization of thymic medulla
small thymus ( J:204710 )
• thymus is smaller than wild-type controls
thymus fibrosis ( J:204710 )
• thymus is fibrotic
abnormal thymus involution ( J:204710 )
• thymus is mostly involuted
decreased double-positive T cell number ( J:204710 )
• reduced numbers of thymic CD4+ CD8+ cells
increased neutrophil cell number ( J:204710 )
• increased neutrophil (Cd11b+ Gr1Hi) population in bone marrow, spleen and blood
decreased B cell number ( J:204710 )
• decrease in numbers of B220+ CD19+ cells in bone marrow
• reduced numbers of B220+ CD19+ cells in the blood; phenotype is more severe in comparison to that observed in Snai3+/-Snai2-/- and Snai3-/-Snai2+/- mice
• reduced numbers of B220+ CD19+ cells in the spleen
increased single-positive T cell number ( J:204710 )
• increase in CD4+ single positive cells
increased macrophage cell number ( J:204710 )
• increased macrophage (Cd11b+ Gr1Int) population in bone marrow and spleen
small spleen ( J:204710 )
• spleen is approximately one third the size of heterozygote controls at 4 weeks of age
disorganized spleen B cell follicle ( J:204710 )
• extensive follicle disorganization is observed in spleens from 6 week old animals
• phenotype is more severe in comparison to Snai3+/-Snai2-/- and Snai3-/-Snai2+/-
• spleen follicles are ringed with a lighter, cell deficient zone

immune system
abnormal thymus cortex morphology ( J:204710 )
• altered organization of thymic cortex
abnormal thymus medulla morphology ( J:204710 )
• altered organization of thymic medulla
small thymus ( J:204710 )
• thymus is smaller than wild-type controls
thymus fibrosis ( J:204710 )
• thymus is fibrotic
abnormal thymus involution ( J:204710 )
• thymus is mostly involuted
decreased double-positive T cell number ( J:204710 )
• reduced numbers of thymic CD4+ CD8+ cells
increased neutrophil cell number ( J:204710 )
• increased neutrophil (Cd11b+ Gr1Hi) population in bone marrow, spleen and blood
decreased B cell number ( J:204710 )
• decrease in numbers of B220+ CD19+ cells in bone marrow
• reduced numbers of B220+ CD19+ cells in the blood; phenotype is more severe in comparison to that observed in Snai3+/-Snai2-/- and Snai3-/-Snai2+/- mice
• reduced numbers of B220+ CD19+ cells in the spleen
increased single-positive T cell number ( J:204710 )
• increase in CD4+ single positive cells
increased macrophage cell number ( J:204710 )
• increased macrophage (Cd11b+ Gr1Int) population in bone marrow and spleen
small spleen ( J:204710 )
• spleen is approximately one third the size of heterozygote controls at 4 weeks of age
disorganized spleen B cell follicle ( J:204710 )
• extensive follicle disorganization is observed in spleens from 6 week old animals
• phenotype is more severe in comparison to Snai3+/-Snai2-/- and Snai3-/-Snai2+/-
• spleen follicles are ringed with a lighter, cell deficient zone

endocrine/exocrine glands
abnormal thymus cortex morphology ( J:204710 )
• altered organization of thymic cortex
abnormal thymus medulla morphology ( J:204710 )
• altered organization of thymic medulla
small thymus ( J:204710 )
• thymus is smaller than wild-type controls
thymus fibrosis ( J:204710 )
• thymus is fibrotic
abnormal thymus involution ( J:204710 )
• thymus is mostly involuted

reproductive system
male infertility ( J:204710 )
• males do not produce offspring

vision/eye
abnormal eye morphology ( J:204710 )
• eye abnormalities are observed




Genotype
MGI:5620264
cx3
Allelic
Composition		 Snai2tm2Grid/Snai2+
Snai3tm1.2Jhws/Snai3tm1.2Jhws
Genetic
Background		 involves: 129/Sv * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai2tm2Grid mutation (1 available); any Snai2 mutation (34 available)
Snai3tm1.2Jhws mutation (0 available); any Snai3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal thymus cortex morphology ( J:204710 )
• altered thymic cortex organization
abnormal thymus medulla morphology ( J:204710 )
• altered thymic medulla organization

hematopoietic system
abnormal thymus cortex morphology ( J:204710 )
• altered thymic cortex organization
abnormal thymus medulla morphology ( J:204710 )
• altered thymic medulla organization
decreased B cell number ( J:204710 )
• reduced numbers of B220+ CD19+ cells in the blood
• phenotype is less severe than that observed in Snai3-/-Snai2-/- and Snai3-/+Snai2-/- mice
disorganized spleen B cell follicle ( J:204710 )
• follicle disorganization observed in spleens from 6 week old animals
• phenotype is less severe than that observed in Snai3-/-Snai2-/- mice

immune system
abnormal thymus cortex morphology ( J:204710 )
• altered thymic cortex organization
abnormal thymus medulla morphology ( J:204710 )
• altered thymic medulla organization
decreased B cell number ( J:204710 )
• reduced numbers of B220+ CD19+ cells in the blood
• phenotype is less severe than that observed in Snai3-/-Snai2-/- and Snai3-/+Snai2-/- mice
disorganized spleen B cell follicle ( J:204710 )
• follicle disorganization observed in spleens from 6 week old animals
• phenotype is less severe than that observed in Snai3-/-Snai2-/- mice




Genotype
MGI:5620265
cx4
Allelic
Composition		 Snai2tm2Grid/Snai2tm2Grid
Snai3tm1.2Jhws/Snai3+
Genetic
Background		 involves: 129/Sv * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai2tm2Grid mutation (1 available); any Snai2 mutation (34 available)
Snai3tm1.2Jhws mutation (0 available); any Snai3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal thymus cortex morphology ( J:204710 )
• altered thymic cortex organization
abnormal thymus medulla morphology ( J:204710 )
• altered thymic medulla organization

hematopoietic system
abnormal thymus cortex morphology ( J:204710 )
• altered thymic cortex organization
abnormal thymus medulla morphology ( J:204710 )
• altered thymic medulla organization
increased neutrophil cell number ( J:204710 )
• increase in number of neutrophils (Cd11b+ Gr1Hi) in the blood from 6 month old mice
decreased B cell number ( J:204710 )
• reduced numbers of B220+ CD19+ cells in the blood
• phenotype is intermediate between Snai3-/-Snai2-/- and Snai3-/-Snai2+/-
increased macrophage cell number ( J:204710 )
• increase in number of macrophages (Cd11b+ Gr1Int) in the blood from 6 month old mice
disorganized spleen B cell follicle ( J:204710 )
• follicle disorganization observed in spleens from 6 week old animals, however, phenotype is less severe than that observed in Snai3-/-Snai2-/- mice

immune system
abnormal thymus cortex morphology ( J:204710 )
• altered thymic cortex organization
abnormal thymus medulla morphology ( J:204710 )
• altered thymic medulla organization
increased neutrophil cell number ( J:204710 )
• increase in number of neutrophils (Cd11b+ Gr1Hi) in the blood from 6 month old mice
decreased B cell number ( J:204710 )
• reduced numbers of B220+ CD19+ cells in the blood
• phenotype is intermediate between Snai3-/-Snai2-/- and Snai3-/-Snai2+/-
increased macrophage cell number ( J:204710 )
• increase in number of macrophages (Cd11b+ Gr1Int) in the blood from 6 month old mice
disorganized spleen B cell follicle ( J:204710 )
• follicle disorganization observed in spleens from 6 week old animals, however, phenotype is less severe than that observed in Snai3-/-Snai2-/- mice




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05/07/2024
MGI 6.23 		The Jackson Laboratory